ReviewBrain research reviews2009
Forebrain pain mechanisms.
Review in Brain research reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
162 citing papers in PubMed, 2 syntheses or guidelines pooled it, 341 citations in OpenAlex.
- Psychological Support for Chronic Low Back Pain: A Systematic Review on the Validity of a Growing Remote Approach.Current pain and headache reports · 2025Pooled it
- Psychological Approaches for the Integrative Care of Chronic Low Back Pain: A Systematic Review and Metanalysis.International journal of environmental research and public health · 2021Pooled it
- Reconsolidation Blockade with Propranolol as a Novel Treatment for Chronic Low-Back Pain: A Double-Blind Randomized Placebo-Controlled Feasibility Study.Journal of pain research · 2026Trial
- Diminished corticomotor excitability in Gulf War Illness related chronic pain symptoms; evidence from TMS study.Scientific reports · 2020Trial
- Depressive attribution style and stressor uncontrollability increase perceived pain intensity after electric skin stimuli in healthy young men.Pain research & managementTrial
- Review
- Structural covariance, regional topology, and volumetric aspects of amygdala subnuclei in posttraumatic stress disorder using ultra-high field imaging.Molecular psychiatry · 2026Article
- Does the predominance of central sensitization alter the effect of balneotherapy combined with conventional physical therapy in patients with chronic low back and knee pain?International journal of biometeorology · 2026Observational
- When pain becomes self: limbic-default mode network hyperconnectivity predicts microvascular decompression failure in trigeminal neuralgia.Brain communications · 2026Article
- Hemifacial Spasm and Blepharospasm: Divergent Social Cognition Performance Despite Similar Neurocognitive Profiles.Brain and behavior · 2025Article
- Chronic unpredictable stress produces hyperalgesia and promotes inhibitory drive in medial prefrontal cortex.The journal of pain · 2025Article
- Alcohol and cannabis use for pain management: Translational findings of relative risks, benefits, and interactions.Physiology & behavior · 2025Review
- Nature exposure induces analgesic effects by acting on nociception-related neural processing.Nature communications · 2025Article
- Affective touch reduces histamine evoked itch experience.PloS one · 2025Article
- Article
- Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons.Molecular and cellular neurosciences · 2024Article
- Modulating Neural Circuits of Pain in Preclinical Models: Recent Insights for Future Therapeutics.Cells · 2024Review
- Chemogenetic Modulation of Posterior Insula CaMKIIa Neurons Alters Pain and Thermoregulation.The journal of pain · 2024Article
- Leptin excites basolateral amygdala principal neurons and reduces food intake by LepRb-JAK2-PI3K-dependent depression of GIRK channels.Journal of cellular physiology · 2024Article
- Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder.Experimental biology and medicine (Maywood, N.J.) · 2024Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Emotional-affective and cognitive dimensions of pain are less well understood than nociceptive and nocifensive components, but the forebrain is believed to play an important role. Recent evidence suggests that subcortical and cortical brain areas outside the traditional pain processing network contribute critically to emotional-affective responses and cognitive deficits related to pain. These brain areas include different nuclei of the amygdala and certain prefrontal cortical areas. Their roles in various aspects of pain will be discussed. Biomarkers of cortical dysfunction are being identified that may evolve into therapeutic targets to modulate pain experience and improve pain-related cognitive impairment. Supporting data from preclinical studies in neuropathic pain models will be presented. Neuroimaging analysis provides evidence for plastic changes in the pain processing brain network. Results of clinical studies in neuropathic pain patients suggest that neuroimaging may help determine mechanisms of altered brain functions in pain as well as monitor the effects of pharmacologic interventions to optimize treatment in individual patients. Recent progress in the analysis of higher brain functions emphasizes the concept of pain as a multidimensional experience and the need for integrative approaches to determine the full spectrum of harmful or protective neurobiological changes in pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.