ArticleDevelopmental biology2009
Cell communication with the neural plate is required for induction of neural markers by BMP inhibition: evidence for homeogenetic induction and implications for Xenopus animal cap and chick explant assays.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- A toolkit for mapping cell identities in relation to neighbors reveals conserved patterning of neuromesodermal progenitor populations.PLoS biology · 2025Article
- The organizer as a cooperative of signaling cells for neural induction.bioRxiv : the preprint server for biology · 2025Article
- Enabling neighbour labelling: using synthetic biology to explore how cells influence their neighbours.Development (Cambridge, England) · 2024Review
- GATA3 is essential for separating patterning domains during facial morphogenesis.Development (Cambridge, England) · 2021Article
- Cadherins in early neural development.Cellular and molecular life sciences : CMLS · 2021Review
- Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.Frontiers in physiology · 2020Review
- Insights Into the Early Gene Regulatory Network Controlling Neural Crest and Placode Fate Choices at the Neural Border.Frontiers in physiology · 2020Review
- Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction.PLoS biology · 2018Article
- Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Ketamine Modulates Zic5 Expression via the Notch Signaling Pathway in Neural Crest Induction.Frontiers in molecular neuroscience · 2018Article
- Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction.Developmental biology · 2017Article
- Signaling pathways and tissue interactions in neural plate border formation.Neurogenesis (Austin, Tex.) · 2017Review
- Article
- Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling.PLoS genetics · 2015Article
- The role of foxi family transcription factors in the development of the ear and jaw.Current topics in developmental biology · 2015Review
- From pluripotency to forebrain patterning: an in vitro journey astride embryonic stem cells.Cellular and molecular life sciences : CMLS · 2014Review
- Article
- Setting appropriate boundaries: fate, patterning and competence at the neural plate border.Developmental biology · 2014Review
- SUMOylation of Pax7 is essential for neural crest and muscle development.Cellular and molecular life sciences : CMLS · 2013Article
- Calfacilitin is a calcium channel modulator essential for initiation of neural plate development.Nature communications · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
In Xenopus, the animal cap is very sensitive to BMP antagonists, which result in neuralization. In chick, however, only cells at the border of the neural plate can be neuralized by BMP inhibition. Here we compare the two systems. BMP antagonists can induce neural plate border markers in both ventral Xenopus epidermis and non-neural chick epiblast. However, BMP antagonism can only neuralize ectodermal cells when the BMP-inhibited cells form a continuous trail connecting them to the neural plate or its border, suggesting that homeogenetic neuralizing factors can only travel between BMP-inhibited cells. Xenopus animal cap explants contain cells fated to contribute to the neural plate border and even to the anterior neural plate, explaining why they are so easily neuralized by BMP-inhibition. Furthermore, chick explants isolated from embryonic epiblast behave like Xenopus animal caps and express border markers. We propose that the animal cap assay in Xenopus and explant assays in the chick are unsuitable for studying instructive signals in neural induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.