Trial reportMaternal & child nutrition2009
Effect of combined maternal and infant vitamin D supplementation on vitamin D status of exclusively breastfed infants.
Trial report in Maternal & child nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01079923 (Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation), which is not on this map. Cited by 23 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation
Who cites it
23 citing papers in PubMed, 6 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Vitamin D status among apparently healthy individuals in the UAE: a systematic review.Frontiers in nutrition · 2025Pooled it
- Calcium, zinc, and vitamin D in breast milk: a systematic review and meta-analysis.International breastfeeding journal · 2023Pooled it
- Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.The Cochrane database of systematic reviews · 2020Pooled it
- Vitamin D in Breastfed Infants: Systematic Review of Alternatives to Daily Supplementation.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- A systematic review and meta-analysis of the response of serum 25-hydroxyvitamin D concentration to vitamin D supplementation from RCTs from around the globe.European journal of clinical nutrition · 2019Pooled it
- Vitamin D supplementation for preventing infections in children under five years of age.The Cochrane database of systematic reviews · 2016Pooled it
- Safety Aspects of a Randomized Clinical Trial of Maternal and Infant Vitamin D Supplementation by Feeding Type Through 7 Months Postpartum.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2020Trial
- Trial
- The change in plasma 25-hydroxyvitamin D did not differ between breast-fed infants that received a daily supplement of ergocalciferol or cholecalciferol for 3 months.The Journal of nutrition · 2013Trial
- Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women.Clinical nutrition (Edinburgh, Scotland) · 2024Article
- Analysis of vitamin DJournal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2024Article
- Correlation between tear levels of vascular endothelial growth factor and vitamin D at retinopathy of prematurity stages in preterm infants.Scientific reports · 2023Article
- Perinatal outcomes of high-dose vitamin D administration in the last trimesterTurkish journal of obstetrics and gynecology · 2021Article
- Update of the tolerable upper intake level for vitamin D for infants.EFSA journal. European Food Safety Authority · 2018Article
- Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.Italian journal of pediatrics · 2018Review
- Overview of Nutrients in Human Milk.Advances in nutrition (Bethesda, Md.) · 2018Review
- Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.The Journal of clinical endocrinology and metabolism · 2016Review
- Iron and vitamin D status in breastfed infants and their mothers.Korean journal of pediatrics · 2015Article
- Hypovitaminosis D in the Middle East and North Africa: Prevalence, risk factors and impact on outcomes.Dermato-endocrinology · 2013Article
- Maternal vitamin D status: effect on milk vitamin D content and vitamin D status of breastfeeding infants.Advances in nutrition (Bethesda, Md.) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe vitamin D deficiency in mothers and their breastfed infants is a significant health problem in the Middle East. Supplementation of the breastfed infant alone with the recommended dose of vitamin D may be insufficient in high-risk population. We investigated the effect of combined maternal and infant vitamin D supplementation on vitamin D status of the breastfed infant. We examined also the effect of supplementation on vitamin D antirachitic activity of breast milk in a subset of mothers. Healthy breastfeeding mothers (n = 90) were randomly assigned to 2000 IU daily (group 1) or 60,000 IU monthly (group 2) of vitamin D(2), and all their infants (n = 92) received 400 IU daily of vitamin D(2) for 3 months. Most infants had vitamin D deficiency - 25-hydroxyvitamin D [25(OH)D] <or= 37.5 nmol L(-1)- at study entry. Serum 25(OH)D concentrations at 3 months increased significantly from baseline in infants of mothers in group 1 (13.9 +/- 8.6 vs. 49.6 +/- 18.5 nmol L(-1), P < 0.0001) and group 2 (13.7 +/- 12.1 vs. 44.6 +/- 15.0 nmol L(-1), P < 0.0001). Maternal and infant serum 25(OH)D concentrations correlated positively at baseline (r = 0.36, P = 0.01) and 3 months (r = 0.46, P = 0.002). Milk antirachitic activity increased from undetectable (<20 IU L(-1)) to a median of 50.9 IU L(-1). In conclusion, combined maternal and infant vitamin D supplementation was associated with a threefold increase in infants' serum 25(OH)D concentrations and a 64% reduction in the prevalence of vitamin D deficiency without causing hypervitaminosis D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.