SynthesisThe Cochrane database of systematic reviews2009
Cholecystectomy for suspected gallbladder dyskinesia.
Synthesis in The Cochrane database of systematic reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- SAGES guidelines for the clinical application of laparoscopic biliary tract surgery.Surgical endoscopy · 2010Guideline
- Pilot Randomized Controlled Trial of Laparoscopic Cholecystectomy vs Active Nonoperative Therapy for the Treatment of Biliary Dyskinesia.Journal of the American College of Surgeons · 2016Trial
- Botulinum toxin-induced relaxation of the sphincter of Oddi may select patients with acalculous biliary pain who will benefit from cholecystectomy.Surgical endoscopy · 2011Trial
- How much pain relief do patients expect after cholecystectomy?Surgical endoscopy · 2018Article
- Decision-making patterns in managing children with suspected biliary dyskinesia.World journal of clinical pediatrics · 2017Article
- Nineteen-year trends in incidence and indications for laparoscopic cholecystectomy: the NY State experience.Surgical endoscopy · 2017Article
- Laparoscopic cholecystectomy: consensus conference-based guidelines.Langenbeck's archives of surgery · 2015Review
- Cholecystectomy for biliary dyskinesia: how did we get there?Digestive diseases and sciences · 2014Review
- Biliary dyskinesia and symptomatic gallstone disease in children: two sides of the same coin?Digestive diseases and sciences · 2014Article
- Biliary dyskinesia: does it exist? If so, how do we diagnose it? Is laparoscopic cholecystectomy effective or a sham operation?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013Review
- Normokinetic biliary dyskinesia: a novel diagnosis.Surgical endoscopy · 2012Article
- Epidemiology of gallbladder disease: cholelithiasis and cancer.Gut and liver · 2012Article
- Biliary dyskinesia: how effective is cholecystectomy?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
- Gallbladder dyskinesia: fact or fiction?Current gastroenterology reports · 2011Review
- Improving Hepatobiliary Imaging as a Physiologic Test with Superior Clinical Outcomes.World journal of nuclear medicineArticle
- Biliary Dyskinesia - Is It Real?JSLS : Journal of the Society of Laparoendoscopic SurgeonsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal treatment for patients with suspected biliary dyskinesia is controversial. Some studies found that cholecystectomy produced symptomatic improvement in patients with gallbladder dyskinesia (diagnosed by low gallbladder ejection fraction) while others found no significant benefit. Some studies have shown that gallbladder ejection fraction can discriminate patients who would benefit from cholecystectomy. Other studies have not confirmed this.
objectivesThe aim of this review was to compare the benefits and harms of cholecystectomy for patients with suspected gallbladder dyskinesia. SEARCH STRATEGY: We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index Expanded until March 2008. SELECTION CRITERIA: We considered for inclusion all randomised clinical trials comparing cholecystectomy versus no cholecystectomy on patients with gallbladder dyskinesia. DATA COLLECTION AND ANALYSIS: We collected the data on the characteristics, methodological quality, mortality, number of patients in whom symptoms were improved or cured from the one identified trial. We planned to analyse the data using the fixed-effect and the random-effects models using RevMan Analysis. For each outcome we planned to calculate the risk ratio (RR) with 95% confidence intervals based on intention-to-treat analysis. MAIN
resultsWe included one trial with 21 patients randomised: 11 to cholecystectomy and 10 to control (no cholecystectomy). This trial was considered to be of high risk of bias as patients were not blinded and the procedure-related morbidity was not reported. There was no mortality in either group. All patients in the cholecystectomy group and only one patient in the control group had improvement in symptoms (P = 0.0001) after a mean follow-up period of 33.6 months. AUTHORS'
conclusionsThe evidence for the benefits and harms of cholecystectomy in gallbladder dyskinesia from randomised clinical trials is based on a single small trial at risk of bias. Further randomised clinical trials with improved bias control are necessary to confirm or reject the promising results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.