SynthesisThe Cochrane database of systematic reviews2009
Interventions for acute non-arteritic central retinal artery occlusion.
Synthesis in The Cochrane database of systematic reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Interventions for acute non-arteritic central retinal artery occlusion.The Cochrane database of systematic reviews · 2023Pooled it
- Thrombolysis for Central Retinal Artery Occlusion in 2020: Time Is Vision!Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2020Pooled it
- [Guidelines from the DOG, RG and BVA: retinal artery occlusion : November 2016 status].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2017Guideline
- [Comparison of superselective intraarterial fibrinolysis with conservative therapy. Use in patients with acute non-arteritic central retinal artery occlusion].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2010Trial
- Management of Visual Loss Following Hyaluronic Acid Filler Injections: An Algorithm-based Approach.Plastic and reconstructive surgery. Global open · 2026Article
- Ocular massage in central retinal artery occlusion: Monitoring vascular recovery with optical coherence tomography angiography - A case series.American journal of ophthalmology case reports · 2026Article
- Effectiveness and safety of superselective ophthalmic artery thrombolysis beyond 24h in central retinal artery occlusion.International journal of ophthalmology · 2026Article
- Staged Management of Vascular Occlusion With Ellansé (Polycaprolactone): A Modified Delphi Expert Consensus.Aesthetic surgery journal. Open forum · 2026Article
- Central Retinal Artery Occlusion: A Review of Pathophysiological Features and Management.Stroke (Hoboken, N.J.) · 2024Review
- Safety and effectiveness of IV Thrombolysis in retinal artery occlusion: A multicenter retrospective cohort study.European stroke journal · 2023Article
- Enhanced external counterpulsation, focusing on its effect on kidney function, and utilization in patients with kidney diseases: a systematic review.Asian biomedicine : research, reviews and news · 2023Review
- Positive Prediction Value of Retinal Artery Occlusion Diagnoses in the Danish National Patient Registry: A Validation Study.Journal of personalized medicine · 2023Article
- Retinal Infarction: A Pilot Study on the Efficacy and Safety of Intravenous Thrombolysis and Underlying Aetiologies.Life (Basel, Switzerland) · 2022Article
- Safety and Efficacy of Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion.Korean journal of ophthalmology : KJO · 2021Article
- Intra-Arterial Tissue Plasminogen Activator for Central Retinal Artery Occlusion.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Hyperbaric Oxygen Therapy for Central Retinal Artery Occlusion: Patient Selection and Perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Development of visual acuity under hyperbaric oxygen treatment (HBO) in non arteritic retinal branch artery occlusion.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Segmenting OCT for detecting drug efficacy in CRAO.PloS one · 2020Article
- Intravenous Hyaluronidase for Visual Loss Secondary to Filler Injection: A Novel Therapeutic Approach.The Journal of clinical and aesthetic dermatology · 2019Review
- Aspirin use in central retinal arterial occlusion to prevent ischaemic stroke: a retrospective cohort study in Taiwan.BMJ open · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute central retinal artery occlusion (CRAO) occurs as a sudden interruption of the blood supply to the retina and results in an almost complete loss of vision in the affected eye. There is no generally agreed treatment regimen although a number of therapeutic interventions have been proposed.
objectivesThe objective of this review was to examine the effects of treatments used for acute non-arteritic CRAO. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library, Issue 3, 2008), MEDLINE (January 1966 to September 2008), EMBASE (January 1980 to September 2008) and the reference lists of relevant papers. SELECTION CRITERIA: We included randomised controlled trials (RCTs) only in which one treatment aimed to re-establish blood supply to the retina in people with acute CRAO was compared to another treatment. DATA COLLECTION AND ANALYSIS: Two authors independently assessed the search results for relevant trials. Discrepancies were resolved by discussion. MAIN
resultsWe found two RCTs that met our inclusion criteria. AUTHORS'
conclusionsThe included studies in this review were small and from single centres. Neither study was completely clear about it's method of treatment allocation. One study described the use of pentoxifylline tablets (three 600 mg tablets daily) and the other the use of enhanced external counterpulsation (EECP) combined with haemodilution. Both studies indicated improved retinal perfusion in the non-control group but neither showed an improvement in vision. Large, well-designed RCTs are still required to establish the most effective treatment for acute CRAO. These studies should be looking at factors important to the patient i.e. improved vision with acceptable risk/side-effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.