SynthesisThe Cochrane database of systematic reviews2009
Cooling therapy for acute stroke.
Synthesis in The Cochrane database of systematic reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Sulfonylurea drugs for people with severe hemispheric ischemic stroke.The Cochrane database of systematic reviews · 2025Pooled it
- Interventions to reduce body temperature to 35 ⁰C to 37 ⁰C in adults and children with traumatic brain injury.The Cochrane database of systematic reviews · 2020Pooled it
- The Role of Hypothermia in Large Hemispheric Infarction: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Modest cooling therapies (35ºC to 37.5ºC) for traumatic brain injury.The Cochrane database of systematic reviews · 2014Pooled it
- Cooling for newborns with hypoxic ischaemic encephalopathy.The Cochrane database of systematic reviews · 2013Pooled it
- Target temperature management in acute ischemic stroke.Frontiers in molecular biosciences · 2026Review
- Management of acute ischemic stroke in the emergency department: optimizing the brain.International journal of emergency medicine · 2025Review
- Targeted Temperature Management for Patients with Acute Ischemic Stroke: A Literature Review.Journal of clinical medicine · 2024Review
- Body temperature in the acute phase and clinical outcomes after acute ischemic stroke.PloS one · 2024Article
- Effects of a 4-Step Standard Operating Procedure for the Treatment of Fever in Patients With Acute Stroke.Frontiers in neurology · 2021Article
- A pilot protocol and review of triple neuroprotection with targeted hypothermia, controlled induced hypertension, and barbiturate infusion during emergency carotid endarterectomy for acute stroke after failed tPA or beyond 24-hour window of opportunity.Annals of translational medicine · 2020Review
- Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.Scientific reports · 2019Article
- Article
- Safety and Efficacy of Hypothermia (34°C) after Hemicraniectomy for Malignant MCA Infarction.Journal of Korean Neurosurgical Society · 2018Article
- Neurorehabilitation: applied neuroplasticity.Journal of neurology · 2017Review
- Normothermia and Stroke.Current treatment options in neurology · 2017Review
- Extended Use of Hypothermia in Elderly Patients with Malignant Cerebral Edema as an Alternative to Hemicraniectomy.Journal of stroke · 2016Article
- Therapeutic hypothermia for acute brain injuries.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Review
- Early temperature and mortality in critically ill patients with acute neurological diseases: trauma and stroke differ from infection.Intensive care medicine · 2015Article
- Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
Corrections and comments
- Update of
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased body temperatures are common in patients with acute stroke and are associated with poor outcome. In animal models of focal cerebral ischaemia, temperature-lowering therapy reduces infarct volume. In patients with acute stroke, lowering temperature may therefore improve outcome. This is an update of a Cochrane review first published in 1999.
objectivesTo assess the effects of pharmacological and physical strategies to reduce body or brain temperature in patients with acute stroke. SEARCH STRATEGY: We searched the Cochrane Stroke Group trials register (last searched December 2007). In addition, we searched MEDLINE and EMBASE (January 1998 to December 2007). We scanned references and contacted authors of included trials. For the previous version of this review, the authors contacted pharmaceutical companies and manufactures of cooling equipment in this field. SELECTION CRITERIA: We considered all completed randomised or non-randomised controlled clinical trials, published or unpublished, where pharmacological or physical strategies or both to reduce temperature were applied in patients with acute ischaemic stroke or intracerebral haemorrhage. Outcome measures were death or dependency (modified Rankin Scale score >/= 3) at the end of follow up, and adverse effects. DATA COLLECTION AND ANALYSIS: Two review authors independently applied the inclusion criteria, assessed trial quality, and extracted and cross-checked the data. MAIN
resultsWe included five pharmacological temperature reduction trials and three physical cooling trials involving a total of 423 participants. We found no statistically significant effect of pharmacological or physical temperature-lowering therapy in reducing the risk of death or dependency (odds ratio (OR) 0.9, 95% confidence interval (CI) 0.6 to 1.4) or death (OR 0.9, 95% CI 0.5 to 1.5). Both interventions were associated with a non-significant increase in the occurrence of infections. AUTHORS'
conclusionsThere is currently no evidence from randomised trials to support routine use of physical or pharmacological strategies to reduce temperature in patients with acute stroke. Large randomised clinical trials are needed to study the effect of such strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.