ArticleDigestive diseases and sciences2009
Serum levels of high-sensitivity C-reactive protein (hs-CRP)in Helicobacter pylori-infected peptic ulcer patients and its association with bacterial CagA virulence factor.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Pooled it
- Is there an association betweenWorld journal of gastroenterology · 2019Pooled it
- Complete blood count-derived inflammatory indices: A noninvasive aid for risk stratification in gastric ulcer.World journal of gastroenterology · 2026Article
- Can neutrophil to lymphocyte ratio be a non-invasive indicator of the presence of duodenal ulcer relatedPractical laboratory medicine · 2023Article
- Hematological Parameters to Predict the Severity of Hyperemesis Gravidarum and Ketonuria.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Article
- Impact ofMicroorganisms · 2021Review
- Relationship BetweenInternational journal of general medicine · 2021Review
- Use of Fourier-Transform Infrared Spectroscopy (FT-IR) for Monitoring ExperimentalInternational journal of molecular sciences · 2020Article
- Association between Helicobacter pylori infection, eradication and diabetes mellitus.Journal of diabetes investigation · 2019Article
- The usefulness of inflammatory biomarkers in diagnosing child and adolescent's gastritis: STROBE compliant article.Medicine · 2019Article
- Inflammation in gastrointestinal disorders: prevalent socioeconomic factors.Clinical and experimental gastroenterology · 2019Article
- Association of a single nucleotide polymorphism in the TLR2 gene (rs3804099), but not in the TLR4 gene (rs4986790), with Helicobacter pylori infection and peptic ulcer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients.International journal of molecular sciences · 2018Article
- Comparison of gastric juice soluble triggering receptor expressed on myeloid cells and C-reactive protein for detection ofElectronic physician · 2017Article
- Serum hsCRP and procalcitonin levels in dyspeptic patients infected with CagA-positive Helicobacter pylori.Journal of clinical laboratory analysis · 2015Article
- Comparison of the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on the Eradication of Helicobacter pylori Infection, Serum Inflammatory Factors and Total Antioxidant Capacity.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Short duration of sleep is associated with elevated high-sensitivity C-reactive protein level in Taiwanese adults: a cross-sectional study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Article
- Serum Helicobacter pylori CagA antibody titer as a useful marker for advanced inflammation in the stomach in Japan.Journal of gastroenterology and hepatology · 2014Article
- A comparative study of broccoli sprouts powder and standard triple therapy on cardiovascular risk factors following H.pylori eradication: a randomized clinical trial in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2014Article
- Lower circulating levels of chemokine CXCL10 in Helicobacter pylori-infected patients with peptic ulcer: Influence of the bacterial virulence factor CagA.Iranian journal of microbiology · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCRP is a marker of inflammation and infection of the gastric mucosa with Helicobacter pylori, which causes an inflammatory reaction. It has been reported that CagA(+) H. pylori strains induce more severe gastric inflammation and are also associated with higher risks of peptic ulcer and gastric cancer. The purpose of this study was to compare serum concentrations of hs-CRP in H. pylori-infected peptic ulcer (PU) patients, H. pylori infected asymptomatic (AS) carriers, and a healthy control group, and their association with bacterial virulence factor CagA. MATERIAL AND
methodsA total of 60 H. pylori infected PU patients (30 patients were positive for anti-CagA antibody and 30 were negative for anti-CagA antibody), 53 H. pylori-infected AS carriers (25 subjects were positive for anti-CagA antibody and 28 were negative for anti-CagA antibody), and 22 healthy H. pylori-negative subjects (as a control group) were enrolled in the study. Serum concentrations of hs-CRP were measured by use of an ELISA method.
resultsThe mean serum level of hs-CRP in all PU patients (124.9±32.4 μg/dl) was significantly higher than that in all AS subjects (18.6±2.6 μg/dl; P<0.001) and the healthy uninfected control group (10.7±2.9 μg/dl; P<0.0001). Moreover, the mean serum level of hs-CRP in the AS group was significantly higher than that observed in the uninfected control group (P<0.04). No significant difference was observed between mean serum levels of hs-CRP of PU patients with positive test for anti-CagA antibody (132.6±49.4 μg/dl) and PU patients with negative test for anti-CagA antibody (117.1±42.9 μg/dl). Moreover, mean serum levels of hs-CRP were similar in AS subjects with positive test for anti-CagA (18.4±3.1 μg/dl) and in those who were negative for anti-CagA antibody (18.9±4.1 μg/dl).
conclusionThe results of this study showed that mean serum concentrations of hs-CRP in PU patients and in H. pylori infected AS carriers were higher than in a healthy control group. Although H. pylori infection is associated with higher serum levels of hs-CRP, serum concentrations of this inflammatory marker were not affected by expression of bacterial CagA virulence factor.
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