ArticleDigestive diseases and sciences2010
Effects of Helicobacter pylori infection on the expressions of Bax and Bcl-2 in patients with chronic gastritis and gastric cancer.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Alanyl-Glutamine Dipeptide MitigatesInternational journal of molecular sciences · 2026Article
- In Silico and Wet Analysis ofCurrent issues in molecular biology · 2025Article
- Effects of Dietary Supplementation with Glutamine on the Immunity and Intestinal Barrier Gene Expression in Broiler Chickens Infected withAnimals : an open access journal from MDPI · 2022Article
- Involvement of microRNA/cystine/glutamate transporter in cold-stressed gastric mucosa injury.Frontiers in pharmacology · 2022Article
- FRA-1 suppresses apoptosis of Helicobacter pylori infected MGC-803 cells.Molecular biology reports · 2021Article
- Molecular Bases of Mechanisms Accounting for Drug Resistance in Gastric Adenocarcinoma.Cancers · 2020Review
- Gastric Damage and Cancer-Associated Biomarkers inFrontiers in microbiology · 2020Review
- Quercetin from Polygonum capitatum Protects against Gastric Inflammation and Apoptosis Associated with Helicobacter pylori Infection by Affecting the Levels of p38MAPK, BCL-2 and BAX.Molecules (Basel, Switzerland) · 2017Article
- Delay in Human Neutrophil Constitutive Apoptosis after Infection withFrontiers in cellular and infection microbiology · 2017Article
- Epigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesis.World journal of gastroenterology · 2015Review
- Helicobacter pylori Infection Activates the Akt-Mdm2-p53 Signaling Pathway in Gastric Epithelial Cells.Digestive diseases and sciences · 2015Article
- Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux.World journal of gastroenterology · 2014Article
- Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients.PloS one · 2011Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study is to evaluate the influence of Helicobacter pylori on Bax and Bcl-2 mRNA and protein levels in patients with chronic gastritis and gastric cancer. The study included 217 patients, of which 26 were uninfected; 127 had chronic gastritis and were H. pylori-positive, and 64 had gastric cancer. Bacterial genotypes were evaluated by PCR, and the expression values were determined by quantitative real-time PCR and immunohistochemistry. Our data showed that the up-regulationary effects of H. pylori infection on the pro-apoptotic gene, Bax, were stronger than its induction of Bcl-2; this effect may increase apoptosis in patients with chronic gastritis. In patients with gastric cancer, the up-regulation of the anti-apoptotic gene, Bcl-2, counteracted the pro-apoptotic effects of Bax, leading to a deregulation of apoptosis-associated gene expression, favoring cell proliferation. Thus, the disturbance in Bax and Bcl-2 balance, induced by H. pylori, might be important in gastric cancer development.
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