ArticleCardiovascular diabetology2009
Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteries.
Article in Cardiovascular diabetology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Effects of empagliflozin on the expression of kisspeptin gene and reproductive system function in streptozotocin-induced diabetic male rats.Frontiers in endocrinology · 2022Article
- Comparison of Pulmonary and Systemic NO- and PGIOxidative medicine and cellular longevity · 2018Article
- Incorporation of bone marrow cells in pancreatic pseudoislets improves posttransplant vascularization and endocrine function.PloS one · 2013Article
- Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats.Cardiovascular diabetology · 2011Article
- Pulmonary arterial dysfunction in insulin resistant obese Zucker rats.Respiratory research · 2011Article
- Hemodynamic and autonomic response to acute hemorrhage in streptozotocin-induced diabetic rats.Cardiovascular diabetology · 2010Article
- Intense exercise training induces adaptation in expression and responsiveness of cardiac β-adrenoceptors in diabetic rats.Cardiovascular diabetology · 2010Article
- Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia.Cardiovascular diabetology · 2010Article
- Sodium-calcium exchange mediated contraction in left anterior descending and left ventricular branch arteries.Journal of cellular and molecular medicine · 2009Article
- Antidiabetic, antihyperlipidemic, and antioxidant activities ofIndian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor control of blood glucose in diabetes is known to promote vascular dysfunction and hypertension. Diabetes was recently shown to be linked to an increased prevalence of pulmonary hypertension. The aim of this study was to determine how the pharmacological reactivity of intrapulmonary arteries is altered in a rat model of diabetes.
methodsDiabetes was induced in rats by the beta-cell toxin, streptozotocin (STZ, 60 mg/kg), and isolated conduit and resistance intrapulmonary arteries studied 3-4 months later. Isometric tension responses to the vasoconstrictors phenylephrine, serotonin and PGF2alpha, and the vasodilators carbachol and glyceryl trinitrate, were compared in STZ-treated rats and age-matched controls.
resultsSTZ-induced diabetes significantly blunted the maximum response of conduit, but not resistance pulmonary arteries to phenylephrine and serotonin, without a change in pEC50. Agonist responses were differentially reduced, with serotonin (46% smaller) affected more than phenylephrine (32% smaller) and responses to PGF2alpha unaltered. Vasoconstriction caused by K+-induced depolarisation remained normal in diabetic rats. Endothelium-dependent dilation to carbachol and endothelium-independent dilation to glyceryl trinitrate were also unaffected.
conclusionThe small resistance pulmonary arteries are relatively resistant to STZ-induced diabetes. The impaired constrictor responsiveness of conduit vessels was agonist dependent, suggesting possible loss of receptor expression or function. The observed effects cannot account for pulmonary hypertension in diabetes, rather the impaired reactivity to vasoconstrictors would counteract the development of pulmonary hypertensive disease.
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