ArticleFEMS immunology and medical microbiology2009
PapR peptide maturation: role of the NprB protease in Bacillus cereus 569 PlcR/PapR global gene regulation.
Article in FEMS immunology and medical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Bacterial Communication: The Possible Role of Quorum Sensing, Quantum Mechanics, and Quantum Tunneling.Metabolites · 2026Review
- The major toxins of Bacillus cereus - Current knowledge on distribution, regulation and mechanism of action.EXCLI journal · 2026Review
- Assessment of antibiofilm and quorum quenching potencies of environmental bacteria in controlling biofilm of food spoilage bacteria.BMC research notes · 2025Article
- From cereus to anthrax and back again: Assessment of the temperature-dependent phenotypic switching in the "cross-over" strainFrontiers in microbiology · 2023Article
- How does Quorum Sensing of Intestinal Bacteria Affect Our Health and Mental Status?Microorganisms · 2022Review
- PapRIV, a BV-2 microglial cell activating quorum sensing peptide.Scientific reports · 2021Article
- The Distribution of Several Genomic Virulence Determinants Does Not Corroborate the Established Serotyping Classification ofInternational journal of molecular sciences · 2021Article
- The Food Poisoning Toxins ofToxins · 2021Review
- Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets.Drug design, development and therapy · 2021Review
- Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk.Frontiers in microbiology · 2021Review
- Article
- Quorum sensing intervened bacterial signaling: Pursuit of its cognizance and repression.Journal, genetic engineering & biotechnology · 2018Review
- Genetic and Structural Analyses of RRNPP Intercellular Peptide Signaling of Gram-Positive Bacteria.Annual review of genetics · 2017Review
- A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster.Molecular microbiology · 2015Article
- CodY Regulates the Activity of the Virulence Quorum Sensor PlcR by Controlling the Import of the Signaling Peptide PapR in Bacillus thuringiensis.Frontiers in microbiology · 2015Article
- Quorum sensing in Bacillus thuringiensis is required for completion of a full infectious cycle in the insect.Toxins · 2014Review
- Peptide-binding dependent conformational changes regulate the transcriptional activity of the quorum-sensor NprR.Nucleic acids research · 2013Article
- Targeting agr- and agr-Like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections.Sensors (Basel, Switzerland) · 2013Review
- Bacterial quorum sensing: its role in virulence and possibilities for its control.Cold Spring Harbor perspectives in medicine · 2012Review
- A novel pheromone quorum-sensing system controls the development of natural competence in Streptococcus thermophilus and Streptococcus salivarius.Journal of bacteriology · 2010Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The global transcriptional regulator PlcR controls gene expression in Bacillus cereus and Bacillus thuringiensis. Activity of PlcR is regulated by PapR, the product of an ORF located immediately downstream of plcR. To be active in B. cereus, PapR must be secreted and then processed to the mature peptide by an unknown protease. This peptide is transported by an oligopeptide permease into the cell, where it activates PlcR. In this study, we show that the neutral protease B (NprB) secreted by B. cereus 569 is required for extracellular PapR maturation. Purified recombinant NprB processed the synthetic PapR propeptide to produce a set of peptides derived from the C-terminal domain of PapR. Supplementation of growth media with synthetic PapR-derived C-terminal 5-, 7-, 8- and 27-amino acid (aa) peptides caused activation of intracellular PlcR in a PapR-deficient strain of B. cereus 569 while only the 5- and 7-aa peptides activated PlcR in a nprB mutant. The maximum activity was found for the 7-mer peptide. However, even the 7-mer peptide could not activate PlcR with a C-terminal truncation of as few as 6 aa. This indicates that interactions of the C-terminal regions of both PlcR and PapR are important in transcriptional activation of the B. cereus 569 PlcR regulon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.