ArticleBioconjugate chemistry2009
Cationic nucleoside lipids based on a 3-nitropyrrole universal base for siRNA delivery.
Article in Bioconjugate chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Rational preparation and application of a mRNA delivery system with cytidinyl/cationic lipid.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- Lipids and Lipid Derivatives for RNA Delivery.Chemical reviews · 2021Review
- Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer.Pharmaceutics · 2021Article
- Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications.Bioconjugate chemistry · 2019Review
- Designer lipids for drug delivery: from heads to tails.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Glycosyl-Nucleolipids as new bioinspired amphiphiles.Molecules (Basel, Switzerland) · 2013Article
- Lipid-based vectors for siRNA delivery.Journal of drug targeting · 2012Review
- Charge-reversal lipids, peptide-based lipids, and nucleoside-based lipids for gene delivery.Accounts of chemical research · 2012Article
- Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices.Nucleic acids research · 2012Review
- Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery.Bioconjugate chemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Cationic nucleoside lipids based on a 3-nitropyrrole universal base were prepared from D-ribose using a straightforward chemical synthesis. Several studies including DLS, TEM, and ethidium bromide (EthBr) assay demonstrated that these amphiphilic molecules form supramolecular organizations of nanometer size in aqueous solutions and are able to bind nucleic acids. siRNA knockdown experiments were performed with these nucleolipids, and we observed protein knockdown activity similar to the siPORT NeoFX positive control. No significant cytotoxicity was found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.