ReviewCell cycle (Georgetown, Tex.)2009
Fine-tuning of nuclear-catenin by Chibby and 14-3-3.
Review in Cell cycle (Georgetown, Tex.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- The Usher syndrome 1C protein harmonin regulates canonical Wnt signaling.Frontiers in cell and developmental biology · 2023Article
- Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling.Frontiers in oncology · 2022Review
- Combined Chibby and β-Catenin Predicts Clinical Outcomes in Patients with Hepatocellular Carcinoma.International journal of molecular sciences · 2020Article
- Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade.Journal of experimental & clinical cancer research : CR · 2018Article
- Anti-oncogenic activity of Chibby in the development of human nasopharyngeal carcinoma.Oncology letters · 2018Article
- Review
- Chibby1 knockdown promotes mesenchymal-to-epithelial transition-like changes.Cell cycle (Georgetown, Tex.) · 2017Article
- Nuclear roles for cilia-associated proteins.Cilia · 2017Review
- Identifying domains of EFHC1 involved in ciliary localization, ciliogenesis, and the regulation of Wnt signaling.Developmental biology · 2016Article
- ELM 2016--data update and new functionality of the eukaryotic linear motif resource.Nucleic acids research · 2016Article
- Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression.Developmental biology · 2014Article
- Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function.Molecular biology of the cell · 2014Article
- No important role for genetic variation in the Chibby gene in monogenic and complex obesity.Molecular biology reports · 2013Article
- Major signaling pathways in intestinal stem cells.Biochimica et biophysica acta · 2013Review
- Chibby suppresses growth of human SW480 colon adenocarcinoma cells through inhibition of β-catenin signaling.Journal of molecular signaling · 2012Article
- Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling.The Journal of cell biology · 2012Article
- β-catenin dosage is a critical determinant of tracheal basal cell fate determination.The American journal of pathology · 2011Article
- Generation and characterization of monoclonal antibodies against human Chibby protein.Hybridoma (2005) · 2011Article
- Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway.Biochemistry · 2011Article
- XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas.The Journal of clinical investigation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chibby (Cby) is an evolutionarily conserved antagonist of beta-catenin, a central player of the canonical Wnt signaling pathway, which acts as a transcriptional coactivator. Cby physically interacts with the C-terminal activation domain of beta-catenin and blocks its transcriptional activation potential through competition with DNA-binding Tcf/Lef transcription factors. Our recent study revealed a second mechanism for Cby-mediated beta-catenin inhibition in which Cby cooperates with 14-3-3 adaptor proteins to facilitate nuclear export of beta-catenin, following phosphorylation of Cby by Akt kinase. Therefore, our findings unravel a novel molecular mechanism regulating the dynamic nucleo-cytoplasmic trafficking of beta-catenin and provide new insights into the cross-talk between the Wnt and Akt signaling pathways. Here, we review recent literature concerning Cby function and discuss our current understanding of the relationship between Wnt and Akt signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.