ArticleMolecular biology of the cell2009
Microtubule and cell contact dependency of ER-bound PTP1B localization in growth cones.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Repurposing Fagonia Indica Alkaloids as Allosteric PTP 1B Inhibitors: Computational Profiling and Biochemical Validation.Cell biochemistry and biophysics · 2025Article
- Spinal PTP1B Regulated NMDA Receptor-mediated Nociceptive Transmission and Peripheral Inflammation-induced Pain Sensitization.Molecular neurobiology · 2025Article
- Protein tyrosine phosphatases in cell adhesion.The Biochemical journal · 2021Review
- Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions.Frontiers in cell and developmental biology · 2021Article
- Neuronal Glycoprotein M6a: An Emerging Molecule in Chemical Synapse Formation and Dysfunction.Frontiers in synaptic neuroscience · 2021Review
- PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility.Biology open · 2015Article
- PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.Molecular biology of the cell · 2015Article
- Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning.PloS one · 2012Article
- ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface.PloS one · 2012Article
- The emerging role of forces in axonal elongation.Progress in neurobiology · 2011Review
- PTP1B regulates Eph receptor function and trafficking.The Journal of cell biology · 2010Article
- The protein tyrosine phosphatase PTP1B is required for efficient delivery of N-cadherin to the cell surface.Molecular biology of the cell · 2010Article
- Protein tyrosine phosphatase PTP1B in cell adhesion and migration.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PTP1B is an ER-bound protein tyrosine phosphatase implied in the regulation of cell adhesion. Here we investigated mechanisms involved in the positioning and dynamics of PTP1B in axonal growth cones and evaluated the role of this enzyme in axons. In growth cones, PTP1B consistently localizes in the central domain, and occasionally at the peripheral region and filopodia. Live imaging of GFP-PTP1B reveals dynamic excursions of fingerlike processes within the peripheral region and filopodia. PTP1B and GFP-PTP1B colocalize with ER markers and coalign with microtubules at the peripheral region and redistribute to the base of the growth cone after treatment with nocodazole, a condition that is reversible. Growth cone contact with cellular targets is accompanied by invasion of PTP1B and stable microtubules in the peripheral region aligned with the contact axis. Functional impairment of PTP1B causes retardation of axon elongation, as well as reduction of growth cone filopodia lifetime and Src activity. Our results highlight the role of microtubules and cell contacts in the positioning of ER-bound PTP1B to the peripheral region of growth cones, which may be required for the positive role of PTP1B in axon elongation, filopodia stabilization, and Src activity.
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