ReviewMolecular pharmacology2009
PAQRs: a counteracting force to ceramides?
Review in Molecular pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Ceramides are fuel gauges on the drive to cardiometabolic disease.Physiological reviews · 2024Review
- Identification of a Specific Plasma Sphingolipid Profile in a Group of Normal-Weight and Obese Subjects: A Novel Approach for a "Biochemical" Diagnosis of Metabolic Syndrome?International journal of molecular sciences · 2023Article
- Metabolic Messengers: ceramides.Nature metabolism · 2019Review
- A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes.The Journal of biological chemistry · 2016Article
- Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Mechanisms linking obesity and cancer.Biochimica et biophysica acta · 2013Review
- Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide.Reviews in endocrine & metabolic disorders · 2013Review
- The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012Article
- Mechanisms of lipotoxicity in the cardiovascular system.Current hypertension reports · 2012Review
- The role of adiponectin in cancer: a review of current evidence.Endocrine reviews · 2012Review
- A role for sphingolipids in the pathophysiology of obesity-induced inflammation.Cellular and molecular life sciences : CMLS · 2012Review
- Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?Diabetes · 2011 · on this mapArticle
- Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.Nature medicine · 2011Article
- The adiponectin receptor homologs in C. elegans promote energy utilization and homeostasis.PloS one · 2011Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In recent years, sphingolipids have garnered increasing attention for their roles in modulating intracellular signaling events. Circulating factors associated with obesity promote excess accumulation of ceramide or glucosylceramide derivatives, which impair insulin action in peripheral tissues. In this issue, Villa et al. (p. 866) provide evidence that, in yeast, the progestin and adipoQ receptor superfamily of receptors mediate their effects via a novel ceramidase activity, generating sphingoid base as a second messenger.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.