ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed, 107 citations in OpenAlex.
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- Optogenetic and thermogenetic manipulation of defined neural circuits and behaviors inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
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- Serotonin receptor 5-HT7 in Drosophila mushroom body neurons mediates larval appetitive olfactory learning.Scientific reports · 2020Article
- Insulin signaling represents a gating mechanism between different memory phases in Drosophila larvae.PLoS genetics · 2020Article
- Dopamine mediates life-history responses to food abundance inProceedings. Biological sciences · 2020Article
- The Neurotransmitters Involved inFrontiers in behavioral neuroscience · 2020Review
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- Selection for associative learning of color stimuli reveals correlated evolution of this learning ability across multiple stimuli and rewards.Evolution; international journal of organic evolution · 2018Article
- Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice.International journal of molecular sciences · 2018Article
- Factors influencing aversive learning in the oriental fruit fly, Bactrocera dorsalis.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae.PloS one · 2017Article
- Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.PLoS genetics · 2016Article
- DISC1 causes associative memory and neurodevelopmental defects in fruit flies.Molecular psychiatry · 2016Article
- Gustatory processing and taste memory in Drosophila.Journal of neurogenetics · 2016Review
- Artificial Induction of Associative Olfactory Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic Neurons in Drosophila Larvae.Frontiers in behavioral neuroscience · 2016Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Associative strength between conditioned stimulus (CS) and unconditioned stimulus (US) is thought to determine learning efficacy in classical conditioning. Elucidation of the neuronal mechanism that underlies the association between CS and US in the brain is thus critical to understand the principle of memory formation. With a simple brain organization, the Drosophila larva provides an attractive model system to investigate learning at the neurocircuitry level. Previously, we described a single-odor paradigm for larval associative learning using sucrose as a reward, and showed that larval appetitive memory lasts longer than 2 h. In this work, we describe behavioral and genetic characterization of larval aversive olfactory memory formed in our paradigm, and compare its stability and neurocircuitry with those of appetitive memory. Despite identical training paradigms, larval olfactory memory formed with quinine or NaCl is short-lived to be lost in 20 min. As with appetitive memory, larval aversive memory produced in this paradigm depends on intact cAMP signaling, but neither mutation of amnesiac nor suppression of CREB activity affects its kinetics. Neurocircuitry analyses suggest that aversive memory is stored before the presynaptic termini of the larval mushroom body neurons as is the case with appetitive memory. However, synaptic output of octopaminergic and dopaminergic neurons, which exhibit distinctive innervation patterns on the larval mushroom body and antennal lobe, is differentially required for the acquisition of appetitive and aversive memory, respectively. These results as a whole suggest that the genetically programmed memory circuitries might provide predisposition in the efficacy of inducing longer-lived memory components in associative learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.