ArticleJournal of clinical microbiology2009
Changes in genetic diversity of the Bordetella pertussis population in the United Kingdom between 1920 and 2006 reflect vaccination coverage and emergence of a single dominant clonal type.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 78 citations in OpenAlex.
- Antibody responses to Bordetella pertussis Fim2 or Fim3 following immunization with a whole-cell, two-component, or five-component acellular pertussis vaccine and following pertussis disease in children in Sweden in 1997 and 2007.Clinical and vaccine immunology : CVI · 2014Trial
- Coping Strategies for Pertussis Resurgence.Vaccines · 2023Review
- Molecular Evolution and Increasing Macrolide Resistance of Bordetella pertussis, Shanghai, China, 2016-2022.Emerging infectious diseases · 2023Article
- Genotypes ofZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022Article
- Molecular epidemiology of Bordetella pertussis and analysis of vaccine antigen genes from clinical isolates from Shenzhen, China.Annals of clinical microbiology and antimicrobials · 2021Article
- Surveillance of Circulating Bordetella pertussis Strains in Europe during 1998 to 2015.Journal of clinical microbiology · 2018Article
- Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines.Microbial genomics · 2018Article
- Molecular epidemiology of Bordetella pertussis in Greece, 2010-2015.Journal of medical microbiology · 2018Article
- Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance.Medical microbiology and immunology · 2018Review
- Severe pertussis infection in infants less than 6 months of age: Clinical manifestations and molecular characterization.Human vaccines & immunotherapeutics · 2017Article
- Short-Read Whole-Genome Sequencing for Laboratory-Based Surveillance of Bordetella pertussis.Journal of clinical microbiology · 2017Article
- Complete Genome Sequences of Bordetella pertussis Vaccine Reference Strains 134 and 10536.Genome announcements · 2016Article
- Direct molecular typing of Bordetella pertussis from nasopharyngeal specimens in China in 2012-2013.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Bordetella pertussis evolution in the (functional) genomics era.Pathogens and disease · 2015Review
- Analysis of Bordetella pertussis clinical isolates circulating in European countries during the period 1998-2012.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Genetic Variation of Bordetella pertussis in Austria.PloS one · 2015Article
- A Proteomic Characterization of Bordetella pertussis Clinical Isolates Associated with a California State Pertussis Outbreak.International journal of proteomics · 2015Article
- Pertussis. A reemerging and an underreported infectious disease.Saudi medical journal · 2014Review
- Molecular epidemiology of the pertussis epidemic in Washington State in 2012.Journal of clinical microbiology · 2014Article
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3 authors.
Funding
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Abstract
Pertussis (whooping cough) is a potentially fatal respiratory disease caused by the bacterium Bordetella pertussis. Despite effective vaccination programs, there has been concern in some developed countries that pertussis cases are on the increase. We characterized 703 clinical B. pertussis isolates collected in the United Kingdom between 1920 and 2006 using multilocus variable-number tandem repeat analysis (MLVA), pertactin (prnA) and pertussis toxin (ptxA) genotyping, and serotyping. The results showed that the genetic diversity of the bacterial population decreased during periods of high vaccine coverage. However, it was elevated between 1977 and 1986, when vaccine coverage in the United Kingdom was low and epidemics occurred. A high proportion of MLVA types during this epidemic period were novel, and the prnA(2) and prnA(3) alleles were seen for the first time in the United Kingdom. MLVA-27 appeared in 1982, was codominant during the 1998-to-2001 period, and comprised approximately 70% of isolates during both the 2002-to-2004 and the 2005-to-2006 periods. The United Kingdom is dominated currently by an MLVA-27 prnA(2) ptxA(1) serotype Fim3 clonal type. Even during recent periods dominated by MLVA-27, many novel types were found at low frequencies, suggesting that either there are a large number of uncommon MLVA types circulating at low frequencies or new types are constantly arising. This supports a hypothesis that MLVA-27 is under some form of positive selection conferring increased survival in a highly vaccinated population. There has been no significant change to the bacterial population in the first 2 years since the United Kingdom switched from a whole-cell to an acellular vaccine.
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