ArticleJournal of clinical microbiology2009
Isolation, antimicrobial resistance, and virulence genes of Pasteurella multocida strains from swine in China.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85 citing papers in PubMed, 192 citations in OpenAlex.
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- Genome sequencing of Pasteurella multocida phage PMP1 elucidates a possible host resistance mechanism and suggests that it belongs to a new species.Archives of virology · 2025Article
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- Molecular epidemiology and characterization of antibiotic resistance ofInternational journal of veterinary science and medicine · 2025Article
- Phenotypical and genotypical resistance testing ofFrontiers in veterinary science · 2025Article
- Characterisation ofAnimals : an open access journal from MDPI · 2024Article
- Molecular characterization of Pasteurella multocida from cats and antibiotic sensitivity of the isolates.Veterinary medicine and science · 2024Article
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- In field evaluation of impact on clinical signs of an inactivated autogenous vaccine againstInternational journal of veterinary science and medicine · 2024Article
- A Comprehensive Review of the Common Bacterial Infections in Dairy Calves and Advanced Strategies for Health Management.Veterinary medicine (Auckland, N.Z.) · 2024Review
- Brazilian Clinical Strains ofAntibiotics (Basel, Switzerland) · 2023Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 233 isolates of Pasteurella multocida were obtained from 2,912 cases of clinical respiratory disease in pigs in China, giving an isolation rate of 8.0%. Serogroup A P. multocida isolates were isolated from 92 cases (39.5%), and serogroup D isolates were isolated from 128 cases (54.9%); 12 isolates (5.2%) were untypeable. P. multocida was the fourth most frequent pathogenic bacterium recovered from the respiratory tract, after Streptococcus suis, Haemophilus parasuis, and Escherichia coli. All isolates were characterized for their susceptibilities to 20 antibiotics and the presence of 19 genes for virulence factors (VFs). The frequency of antimicrobial resistance among P. multocida isolates from swine in China was higher than that reported among P. multocida isolates from swine in from other countries, and 93.1% of the isolates showed multiple-drug resistance. There was a progressive increase in the rate of multiresistance to more than seven antibiotics, from 16.2% in 2003 to 62.8% in 2007. The resistance profiles suggested that cephalosporins, florfenicol, and fluoroquinolones were the drugs most likely to be active against P. multocida. Use of PCR showed that colonization factors (ptfA, fimA, and hsf-2), iron acquisition factors, sialidases (nanH), and outer membrane proteins occurred in most porcine strains. The VFs pfhA, tadD, toxA, and pmHAS were each present in <50% of strains. The various VFs exhibited distinctive associations with serogroups: concentrated in serogroup A, concentrated in serogroup D, or occurring jointly in serogroups A and D. These findings provide novel insights into the epidemiological characteristics of porcine P. multocida isolates and suggest that the potential threat of such multiresistant bacteria in food-producing animals should not be neglected.
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