ArticleDevelopment (Cambridge, England)2009
Identification of direct T-box target genes in the developing zebrafish mesoderm.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state.PLoS genetics · 2026Article
- Stage- and tissue-specific gene editing using 4-OHT-inducible Cas9 in whole organism.The Journal of cell biology · 2026Article
- Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops.Frontiers in cell and developmental biology · 2022Article
- Hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development.Development (Cambridge, England) · 2020Article
- Fgf-driven Tbx protein activities directly induceDevelopment (Cambridge, England) · 2020Article
- Tris(1,3-dichloro-2-propyl) Phosphate Exposure During the Early-Blastula Stage Alters the Normal Trajectory of Zebrafish Embryogenesis.Environmental science & technology · 2018Article
- Presomitic mesoderm-specific expression of the transcriptional repressorThe Journal of biological chemistry · 2018Article
- Lamin A, Chromatin and FPLD2: Not Just a PeripheralFrontiers in cell and developmental biology · 2018Review
- tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors.Cell reports · 2017Article
- Tbx16 regulates hox gene activation in mesodermal progenitor cells.Nature chemical biology · 2016Article
- A novel cold-sensitive mutant of ntla reveals temporal roles of brachyury in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Tales of Tails (and Trunks): Forming the Posterior Body in Vertebrate Embryos.Current topics in developmental biology · 2016Review
- Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.Developmental biology · 2015Article
- Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm.Development (Cambridge, England) · 2015Article
- Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.Development (Cambridge, England) · 2015Article
- Zebrafish Tbx16 regulates intermediate mesoderm cell fate by attenuating Fgf activity.Developmental biology · 2013Article
- Early evolution of the T-box transcription factor family.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Functional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochord.PLoS biology · 2013Article
- An intact brachyury function is necessary to prevent spurious axial development in Xenopus laevis.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The zebrafish genes spadetail (spt) and no tail (ntl) encode T-box transcription factors that are important for early mesoderm development. Although much has been done to characterize these genes, the identity and location of target regulatory elements remain largely unknown. Here, we survey the genome for downstream target genes of the Spt and Ntl T-box transcription factors. We find evidence for extensive additive interactions towards gene activation and limited evidence for combinatorial and antagonistic interactions between the two factors. Using in vitro binding selection assays to define Spt- and Ntl-binding motifs, we searched for target regulatory sequence via a combination of binding motif searches and comparative genomics. We identified regulatory elements for tbx6 and deltaD, and, using chromatin immunoprecipitation, in vitro DNA binding assays and transgenic methods, we provide evidence that both are directly regulated by T-box transcription factors. We also find that deltaD is directly activated by T-box factors in the tail bud, where it has been implicated in starting the segmentation clock, suggesting that spt and ntl act upstream of this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.