ArticleDevelopment (Cambridge, England)2009
FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 88 citations in OpenAlex.
- Somatic cells non-autonomously control germline incomplete cytokinesis through FGF signaling.bioRxiv : the preprint server for biology · 2026Article
- In Vivo Models of Cardiovascular Disease:Biomedicines · 2025Review
- Cytoneme feedback ensures signaling specificity when multiple ligands converge on a common receptor.bioRxiv : the preprint server for biology · 2025Article
- Article
- Functional evidence that FGFR regulates MAPK signaling in organizer specification in the gastropod molluskMarine life science & technology · 2023Article
- Drosophila FGFR/Htl signaling shapes embryonic glia to phagocytose apoptotic neurons.Cell death discovery · 2023Article
- The context-dependent, combinatorial logic of BMP signaling.Cell systems · 2022Article
- A genetic screen for regulators of muscle morphogenesis in Drosophila.G3 (Bethesda, Md.) · 2021Article
- Article
- Spatiotemporal sensitivity of mesoderm specification to FGFR signalling in the Drosophila embryo.Scientific reports · 2021Article
- FGF signaling acts on different levels of mesoderm development within Spiralia.Development (Cambridge, England) · 2021Article
- Single-cell transcriptomics of theeLife · 2021Article
- The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling.eLife · 2021Article
- FGF Pyramus Has a Transmembrane Domain and Cell-Autonomous Function in Polarity.Current biology : CB · 2020Article
- FGF signaling promotes myoblast proliferation through activation of wingless signaling.Developmental biology · 2020Article
- Collective Migrations ofGenetics · 2020Review
- FGF signaling directs myotube guidance by regulating Rac activity.Development (Cambridge, England) · 2020Article
- FGF receptors are required for proper axonal branch targeting in Drosophila.Molecular brain · 2019Article
- Discoidin-domain receptor coordinates cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors.Nature communications · 2019Article
- FGF controls epithelial-mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity.Development (Cambridge, England) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Fibroblast growth factor (FGF) signaling controls a vast array of biological processes including cell differentiation and migration, wound healing and malignancy. In vertebrates, FGF signaling is complex, with over 100 predicted FGF ligand-receptor combinations. Drosophila melanogaster presents a simpler model system in which to study FGF signaling, with only three ligands and two FGF receptors (FGFRs) identified. Here we analyze the specificity of FGFR [Heartless (Htl) and Breathless (Btl)] activation by each of the FGF ligands [Pyramus (Pyr), Thisbe (Ths) and Branchless (Bnl)] in Drosophila. We confirm that both Pyr and Ths can activate Htl, and that only Bnl can activate Btl. To examine the role of each ligand in supporting activation of the Htl FGFR, we utilize genetic approaches that focus on the earliest stages of embryonic development. When pyr and ths are equivalently expressed using the Gal4 system, these ligands support qualitatively different FGFR signaling responses. Both Pyr and Ths function in a non-autonomous fashion to support mesoderm spreading during gastrulation, but Pyr exhibits a longer functional range. pyr and ths single mutants exhibit defects in mesoderm spreading during gastrulation, yet only pyr mutants exhibit severe defects in dorsal mesoderm specification. We demonstrate that the Drosophila FGFs have different activities and that cell migration and differentiation have different ligand requirements. Furthermore, these FGF ligands are not regulated solely by differential expression, but the sequences of these linked genes have evolved to serve different functions. We contend that inherent properties of FGF ligands make them suitable to support specific FGF-dependent processes, and that FGF ligands are not always interchangeable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.