ArticleThe Journal of biological chemistry2009
KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- The post-stroke young adult brain has limited capacity to re-express the gene expression patterns seen during early postnatal brain development.Brain pathology (Zurich, Switzerland) · 2024Article
- Anterograde Axonal Transport in Neuronal Homeostasis and Disease.Frontiers in molecular neuroscience · 2020Review
- Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.The Journal of cell biology · 2018Article
- Ribosomal protein NtRPL17 interacts with kinesin-12 family protein NtKRP and functions in the regulation of embryo/seed size and radicle growth.Journal of experimental botany · 2017Article
- Involvement of SARA in Axon and Dendrite Growth.PloS one · 2015Article
- Hop-on hop-off: polysomes take a tour of the cell on endosomes.The Journal of cell biology · 2014Article
- Early endosome motility spatially organizes polysome distribution.The Journal of cell biology · 2014Article
- Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.PloS one · 2014Article
- Unconventional functions of microtubule motors.Archives of biochemistry and biophysics · 2012Review
- Kinesin molecular motor Eg5 functions during polypeptide synthesis.Molecular biology of the cell · 2011Article
- RNA granules: the good, the bad and the ugly.Cellular signalling · 2011Review
- Evidence for the involvement of Lfc and Tctex-1 in axon formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Chromatin maintenance by a molecular motor protein.Nucleus (Austin, Tex.)Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we have used a combination of biochemical and molecular biology techniques to demonstrate that the C-terminal tail domain of KIF4 directly interacts with P0, a major protein component of ribosomes. Besides, in dorsal root ganglion neurons, KIF4 and P0, as well as other ribosomal constituents, colocalize in clusters distributed along axons and neuritic tips. RNA interference suppression of KIF4 or expression of KIF4 variants lacking the tail domain or mutations of the ATP-binding site result in accumulation of P0 and other ribosomal proteins at the cell body and in their disappearance from axons. Our results also show one additional function for KIF4 involving an Ezrin-Radixin-Moesin-like domain in the second coiled-coiled region of KIF4. Expression of a KIF4 mutant lacking this domain abolishes the clustering of ribosomal constituents and prevents the anterograde translocation of the cell adhesion molecule L1. Taken together, the present results suggest that by binding to P0 through its tail domain and by using its motor activity, KIF4 is involved in the anterograde trafficking of ribosomal constituents to axons and that by means of its Ezrin-Radixin-Moesin-like domain interacts and transports L1.
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Registered trials
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