ArticleJournal of molecular neuroscience : MN2009
The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling.
Article in Journal of molecular neuroscience : MN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 15 citations in OpenAlex.
- Stable knockdown of Drp1 improves retinoic acid-BDNF-induced neuronal differentiation through global transcriptomic changes and results in reduced phosphorylation of ERK1/2 independently of DUSP1 and 6.Frontiers in cell and developmental biology · 2024Article
- Obesity as a Risk Factor for Alzheimer's Disease: Implication of Leptin and Glutamate.Frontiers in neuroscience · 2019Article
- Role of Astrocytes in Leptin Signaling.Journal of molecular neuroscience : MN · 2015Article
- Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Protective role of astrocytic leptin signaling against excitotoxicity.Journal of molecular neuroscience : MN · 2013Article
- Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis.Journal of molecular neuroscience : MN · 2012Article
- Cytokine signaling modulates blood-brain barrier function.Current pharmaceutical design · 2011Review
- Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice.Journal of molecular neuroscience : MN · 2011Article
- Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells.Journal of neurochemistry · 2010Article
- Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Melanocortin potentiates leptin-induced STAT3 signaling via MAPK pathway.Journal of neurochemistry · 2009Article
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4 authors at 1 institution in 1 country.
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Abstract
Cyclin-dependent kinase (Cdk) 5 is ubiquitously expressed in the brain and plays an essential role in central nervous system development and synaptic plasticity. The p35 kinase is a neuronal specific activator of Cdk5. Here, we show for the first time that Cdk5 activation modulates leptin signaling. P35 and its metabolite p25 were colocalized with the leptin receptor ObR in selective neurons in the hypothalamus. Overexpression of p35 alone was sufficient to induce the transcriptional activation of signal transducer and activator of transcription 3 (STAT3) in a cellular model. In retinoic acid-differentiated SH-SY5Y neuronal cells where ObRb was induced, leptin increased the expression of Cdk5, p35, and p25 kinases. The time course of induction coincided with that of phosphorylated (p)-STAT3. When Cdk5 activity was inhibited, either by roscovitine or overexpression of dominant negative Cdk5, there was a reduction of pSTAT3 activation. The results show that the activation of Cdk5 by p35 sustained leptin-induced pSTAT3 at 3-6 h. Thus, p35 is a novel modulator of leptin-induced STAT3 signaling.
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