Trial reportCerebellum (London, England)2009
Reduced cerebellar inhibition in migraine with aura: a TMS study.
Trial report in Cerebellum (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The cerebellum in migraine: a narrative review of anatomical, imaging, and clinical evidence.Frontiers in neurology · 2026Pooled it
- Efficacy of single versus three sessions of high rate repetitive transcranial magnetic stimulation in chronic migraine and tension-type headache.Journal of neurology · 2016Trial
- Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Review
- Effect of Low Frequency Cerebellar Repetitive Transcranial Magnetic Stimulation on Balance Impairment in Patients With Cerebral Infarction.Annals of rehabilitation medicine · 2022Article
- Involvement of the cerebellum in migraine.Frontiers in systems neuroscience · 2022Review
- Reflexive and Intentional Saccadic Eye Movements in Migraineurs.Frontiers in neurology · 2021Article
- Migraine With Aura Is Related to Delayed Motor Control Reaction and Imbalance Following External Perturbations.Frontiers in neurology · 2021Article
- Transcranial Direct Current Stimulation of the Occipital Cortex in Medication Overuse Headache: A Pilot Randomized Controlled Cross-Over Study.Journal of clinical medicine · 2020Article
- A case-control study of visually evoked postural responses in childhood with primary headaches.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Functional Alterations in the Posterior Insula and Cerebellum in Migraine Without Aura: A Resting-State MRI Study.Frontiers in behavioral neuroscience · 2020Article
- Sensory Neuromodulation.Frontiers in systems neuroscience · 2020Article
- Cathodal Transcranial Direct Current Stimulation of the Occipital cortex in Episodic Migraine: A Randomized Sham-Controlled Crossover Study.Journal of clinical medicine · 2019Article
- Advanced visual network and cerebellar hyperresponsiveness to trigeminal nociception in migraine with aura.The journal of headache and pain · 2019Article
- Targeting the Cerebellum by Noninvasive Neurostimulation: a Review.Cerebellum (London, England) · 2017Review
- Visual cortex and cerebellum hyperactivation during negative emotion picture stimuli in migraine patients.Scientific reports · 2017Article
- Cerebellar function and ischemic brain lesions in migraine patients from the general population.Cephalalgia : an international journal of headache · 2017Article
- Spatial Heterogeneity of Cortical Excitability in Migraine Revealed by Multifrequency Neuromagnetic Signals.The journal of pain · 2016Article
- CGRP mechanism antagonists and migraine management.Current neurology and neuroscience reports · 2015Review
- Motor coordination impairment and migraine in children: a new comorbidity?European journal of pediatrics · 2012Article
- Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia.Human brain mapping · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subtle clinical cerebellar alterations have been found in migraine. Moreover, abnormalities in visual and motor cortex excitability consistent with a lack of inhibitory efficiency have been described in migraine, and it is known that cerebellum exerts an inhibitory control on cerebral cortex. Here, we investigated if impairment of cerebellar activity on motor cortex, i.e. reduced inhibitory control, can be found in migraine. Ten migraineurs with aura and seven healthy controls underwent a transcranial magnetic stimulation (TMS) protocol to investigate the cerebellar inhibitory drive on motor cortex: a conditioning pulse on right cerebellar cortex was delivered 5, 7, 10, 15 ms before a test stimulus (TS) on contralateral motor cortex. The cerebellar conditioning stimulus inhibits the size of the motor-evoked potential (MEP) produced by the TS alone by approximately 30-50%. Amplitude of MEP to TS alone showed no significant difference between patients and controls. Cerebellar conditioning TMS showed a significant deficit of cerebellar inhibition in migraine patients as compared to controls at all interstimulus intervals (5-15 ms) tested. Cerebellar inhibition is reduced in migraineurs. This could account, at least in part, for the reduced inhibitory efficiency previously showed in cerebral cortex of these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.