ArticleLipids2009
Early dissimilar fates of liver eicosapentaenoic acid in rats fed liposomes or fish oil and gene expression related to lipid metabolism.
Article in Lipids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 15 citations in OpenAlex.
- Marine Lipids and Alzheimer's Disease: Biochemistry, Bioaccessibility/Bioavailability, Metabolism, and Health Effects.Marine drugs · 2026Review
- Nutritional properties of dietary omega-3-enriched phospholipids.BioMed research international · 2013Review
- Marine omega-3 phospholipids: metabolism and biological activities.International journal of molecular sciences · 2012Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study was undertaken to determine whether eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3), esterified in phospholipids (PL) as liposomes or in triglycerides (TG) as oil, exhibited comparable fates in liver lipids and whether these fates were associated with gene expressions related to fatty acid (FA) metabolism. PL and TG mixtures with close contents in EPA and DHA were administered to rats over 2 weeks. Most relevant events occurred after 3 days for both treatments. At that time, liposomes, compared with oil, increased the liver content in PL with a FA composition enriched in n-6 FA, comparable in DHA and much lower in EPA. Moreover, liposomes increased the activity and mRNA levels of carnitine palmitoyltransferase (CPT) I. In contrast, fish oil exerted opposite effects on CPT I and increased the genic expression of lipogenic enzymes. Liposomes, unlike fish oil, apparently increased the mRNA levels of acyl-CoA oxidase and the activity of the peroxisomal FA-oxidising system. Concomitantly, mRNA levels of hepatic lipoprotein receptors were increased with both diets, but intracellular proteins involved in free FA uptake and lipid synthesis were up-regulated only with liposome-treated rats. The quasi absence of EPA in hepatic PL of liposome-treated rats on the short term could result from increased beta-oxidation activities through metabolic regulations induced by more available free EPA and other PUFA.
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Registered trials
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