ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2009
Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Use of antipsychotics increases the risk of fracture: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Choice of observational study design impacts on measurement of antipsychotic risks in the elderly: a systematic review.BMC medical research methodology · 2012Pooled it
- Is it possible to identify risks for injurious falls in hospitalized patients?Joint Commission journal on quality and patient safety · 2012Trial
- Article
- Association of schizophrenia with fracture-related femoral neck displacement: A cross-sectional retrospective study.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Antipsychotic medication use and fracture: a case-control study.Scientific reports · 2023Article
- Bone Health in Adults With Prader-Willi Syndrome: Clinical Recommendations Based on a Multicenter Cohort Study.The Journal of clinical endocrinology and metabolism · 2022Article
- [Hip fractures in patients treated with antipsychotic drugs. Study of retrospective cohorts in Catalonia].Atencion primaria · 2022Article
- Use of antipsychotic drugs and cholinesterase inhibitors and risk of falls and fractures: self-controlled case series.BMJ (Clinical research ed.) · 2021Observational
- Association between Anti-Psychotic Drugs Use and Hip Fractures in Patients with Dementia: A Nationwide Population-Based Study.International journal of environmental research and public health · 2021Article
- Antipsychotic Medication in Schizophrenic Patients is Associated with Higher Risks of Developing Bone Fractures and Refractures.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Hyperprolactinemia and bone.Pituitary · 2020Review
- Serum Prolactin and Bone Mineral Density in Schizophrenia: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- All-cause mortality with current and past use of antidepressants or benzodiazepines after major osteoporotic and hip fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Low risk for hip fracture and high risk for hip arthroplasty due to osteoarthritis among Swedish farmers.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine.BMC pharmacology & toxicology · 2017Article
- Parameters of Calcium Metabolism Fluctuated during Initiation or Changing of Antipsychotic Drugs.Psychiatry investigation · 2016Article
- Do antipsychotics cause hip fractures? Promise and pitfalls of big data.The Journal of clinical psychiatry · 2015Article
- Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2015Article
- Risk and adverse outcomes of fractures in patients with Parkinson's disease: two nationwide studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
unlabelledThis case-control study showed that current use of conventional antipsychotics, but not atypical antipsychotics, seems to be associated with an increased risk of a hip/femur fracture, possibly related to the pharmacological properties of conventional antipsychotics. Furthermore, no evidence for a dose effect was found.
introductionThe aim of this study was to assess the risk of hip/femur fracture associated with antipsychotic use, with particular reference to any difference in risk with conventional versus atypical antipsychotics, dose, and pharmacological properties.
methodsA case-control study was conducted using data from the PHARMO Record Linkage System among individuals aged 18 years and older between 1991 and 2002. Cases had a record of a hip or femur fracture, while controls had no evidence of ever having sustained any fracture.
resultsMost cases were elderly (77.6% aged > or = 70 years). We found an increased risk for hip/femur fracture associated with the use of antipsychotic drugs. The risk for current users (OR(adj) 1.68 [1.43, 1.99]) was significantly greater than with past use (OR(adj) 1.33 [1.14, 1.56]; p = 0.036). Current use of conventional antipsychotics (OR(adj) 1.76 [1.48, 2.08]) but not atypical antipsychotics (OR(adj) 0.83 [0.42, 1.65]) was associated with an increased risk. We did not find evidence for a dose effect.
conclusionThe use of conventional, but not atypical antipsychotics, seems to be associated with an increased risk of hip/femur fracture, possibly related to the pharmacological properties of conventional antipsychotics. However, the numbers of atypical antipsychotic users were small, and therefore this observation needs further attention in other study populations.
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Registered trials
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