ArticleEuropean journal of clinical nutrition2009
Prevalence of adult-type hypolactasia as diagnosed with genetic and lactose hydrogen breath tests in Hungarians.
Article in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Clinical Utility ofNutrients · 2020Observational
- Observational
- Clinical evaluation, biochemistry and genetic polymorphism analysis for the diagnosis of lactose intolerance in a population from northeastern Brazil.Clinics (Sao Paulo, Brazil) · 2016Review
- High osteoporosis risk among East Africans linked to lactase persistence genotype.BoneKEy reports · 2016Article
- Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry.Journal of pediatric gastroenterology and nutrition · 2015Article
- Evolution of lactase persistence: an example of human niche construction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
- Theodore E. Woodward Award: lactase persistence SNPs in African populations regulate promoter activity in intestinal cell culture.Transactions of the American Clinical and Climatological Association · 2011Article
- A worldwide correlation of lactase persistence phenotype and genotypes.BMC evolutionary biology · 2010Article
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Authors and funding
8 authors.
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Abstract
The prevalence of adult-type hypolactasia varies ethnically and geographically among populations. A C/T(-13910) single nucleotide polymorphism (SNP), upstream of the lactase gene, is known to be associated with lactase non-persistence. The aim of this study was to determine the prevalence of lactase-persistent and non-persistent genotypes in the Hungarian population, the age at onset and the applicability of the lactose H2 breath test in comparison with genetic screening. The prevalence of the C/C(-13910) genotype among adults was 37%. Hypolactasia starts to appear at around 5 years of age. Over the age of 12 years, almost all of those with a C/C(-13910) genotype have lactase non-persistence. The C/C(-13910) genotype was closely associated with a positive lactose H2 breath test in symptomatic children, whereas the lactase-persistent genotypes correlated better with a negative H2 test in a control group. In conclusion, supplementary non-invasive breath and genotyping tests furnish a perfect clinical diagnosis.
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