ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2009
Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2012Trial
- Conversion to Mild Cognitive Impairment and Alzheimer's Disease Dementia Related to Apathy,Journal of geriatric psychiatry and neurology · 2025Article
- Substance use moderates relationships between apolipoprotein E genotype, hepatitis C, cognition, and depression in Miami Adult Studies on HIV (MASH) participants.Journal of neurovirology · 2024Article
- Association Between Elevated Depressive Symptoms and Cognitive Function Moderated by APOE4 Status: Framingham Offspring Study.Journal of Alzheimer's disease : JAD · 2021Article
- Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia.Journal of the International Neuropsychological Society : JINS · 2019Article
- Article
- APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.Brain imaging and behavior · 2017Article
- Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice.Molecular neurodegeneration · 2016Article
- Association between depressive symptoms, use of antidepressant medication and the metabolic syndrome: the Maine-Syracuse Study.BMC public health · 2016Article
- DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women.Frontiers in genetics · 2015Article
- Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E ε4 allele in nondemented elderly: a preliminary study.Journal of affective disorders · 2014Article
- Gene-behavior interaction of depressive symptoms and the apolipoprotein E {varepsilon}4 allele on cognitive decline.Psychosomatic medicine · 2014Article
- Presepsis depressive symptoms are associated with incident cognitive impairment in survivors of severe sepsis: a prospective cohort study of older Americans.Journal of the American Geriatrics Society · 2012Article
- The moderating effect of the APOE [small element of] 4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2011Article
- Apolipoprotein e4 genotype and depressive symptoms as risk factors for dementia in an older korean population.Psychiatry investigation · 2010Article
- Comorbid depression is associated with an increased risk of dementia diagnosis in patients with diabetes: a prospective cohort study.Journal of general internal medicine · 2010Article
- A multiplicity of approaches to characterize geriatric depression and its outcomes.Current opinion in psychiatry · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectivesThe apolipoproteinE epsilon4 (APOE epsilon4) allele and a history of depression are each separate risk factors for cognitive decline (CD). However, little research has investigated whether a history of depression influences the relationship between APOE epsilon4 and CD. The present study examined whether depressive symptoms had greater influence on subsequent CD among participants with APOE epsilon4 than those without the allele.
designProspective 6-year longitudinal study.
settingCommunity in-home interviews.
participantsA biracial sample of community dwelling older adults (N = 1,992) from the Duke Established Populations for Epidemiologic Studies of the Elderly (EPESE). MEASUREMENTS: Data were drawn from Waves 1 to 3 of the EPESE, which were conducted 6 years apart. Cognitive functioning and depressive symptoms were assessed at both waves, and APOE genotyping was completed during the Wave 3 assessment.
resultsRegression analyses revealed that depressive symptoms and the APOE epsilon4 allele independently predicted CD. Importantly, the influence of depressive symptoms on CD was greater for individuals with the APOE epsilon4 allele compared with those without the allele.
conclusionDepressive symptoms and the APOE epsilon4 allele are independent contributors to CD. Moreover, the influence of depressive symptoms on CD is greater among individuals with the APOE epsilon4 allele. Depression and the APOE epsilon4 allele may act together in disrupting neurological functioning, which may in turn lower an individual's cognitive reserve capacity. Given the efficacious treatments currently available for depression, future research should investigate the extent to which interventions for depression may reduce the risk for subsequent CD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.