ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Macrophages activated by C-reactive protein through Fc gamma RI transfer suppression of immune thrombocytopenia.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Assessment of rs1205 and rs1130864 Polymorphisms of C-Reactive Protein Gene (Health science reports · 2025Article
- The contribution of the CRP/CD64 axis to renal cancer progression by inducing protumor activation of tumor-associated macrophages.Clinical & translational immunology · 2024Article
- Role of high‑sensitivity C‑reactive protein in patients with sarcoma.Oncology letters · 2023Article
- Monomeric C-reactive protein level is associated with osteoarthritis.Experimental and therapeutic medicine · 2022Article
- C-Reactive Protein Is an Indicator of the Immunosuppressive Microenvironment Fostered by Myeloid Cells in Hepatocellular Carcinoma.Frontiers in oncology · 2021Article
- The Efficacy of Posttreatment with Synthetic C-Reactive Protein in Murine Bacterial Peritonitis via Activation of FcγRI-Expressing Kupffer Cells.Journal of innate immunity · 2021Article
- Pentraxins and Fc Receptor-Mediated Immune Responses.Frontiers in immunology · 2018Review
- Pentraxins: structure, function, and role in inflammation.ISRN inflammation · 2013Review
- C-reactive protein inhibits plasmacytoid dendritic cell interferon responses to autoantibody immune complexes.Arthritis and rheumatism · 2013Article
- Pentraxins and Fc receptors.Immunological reviews · 2012Review
- Megakaryocyte progenitors are the main APCs inducing Th17 response to lupus autoantigens and foreign antigens.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- C-reactive protein functions as a negative regulator of macrophage activation induced by apoptotic DNA.Protein & cell · 2011Article
- Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors.Current opinion in organ transplantation · 2011Review
- C-reactive protein-mediated vascular injury requires complement.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Adoptive-transfer effects of intravenous immunoglobulin in autoimmunity.Journal of clinical immunology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
C-reactive protein (CRP) is an acute-phase protein with therapeutic activity in mouse models of systemic lupus erythematosus and other inflammatory and autoimmune diseases. To determine the mechanism by which CRP suppresses immune complex disease, an adoptive transfer system was developed in a model of immune thrombocytopenic purpura (ITP). Injection of 200 microg of CRP 24 h before induction of ITP markedly decreased thrombocytopenia induced by anti-CD41. CRP-treated splenocytes also provided protection from ITP in adoptive transfer. Splenocytes from C57BL/6 mice were treated with 200 microg/ml CRP for 30 min, washed, and injected into mice 24 h before induction of ITP. Injection of 10(6) CRP-treated splenocytes protected mice from thrombocytopenia, as did i.v. Ig-treated but not BSA-treated splenocytes. The suppressive cell induced by CRP was found to be a macrophage by depletion, enrichment, and the use of purified bone marrow-derived macrophages. The induction of protection by CRP-treated cells was dependent on FcRgamma-chain and Syk activation, indicating an activating effect of CRP on the donor cell. Suppression of ITP by CRP-treated splenocytes required Fc gamma RI on the donor cell and Fc gamma RIIb in the recipient mice. These findings suggest that CRP generates suppressive macrophages through Fc gamma RI, which then act through an Fc gamma RIIb-dependent pathway in the recipient to decrease platelet clearance. These results provide insight into the mechanism of CRP regulatory activity in autoimmunity and suggest a potential new therapeutic approach to ITP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.