Evidence map›Paper›PMID 19155345›Full record

ReviewSchizophrenia bulletin2009

Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring.

Klaas E Stephan, Karl J Friston, Chris D Frith

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Schizophrenia bulletin, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 545 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
545citing papers in PubMed, 7 pooled it
25.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

545 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,138 citations in OpenAlex.

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485 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 4 countries.

Klaas E Stephank.stephan@fil.ion.ucl.ac.uk
Karl J Friston
Chris D Frith
Laboratory for Social and Neural Systems Research · CHNational Hospital for Neurology and Neurosurgery · GBWellcome Centre for Human Neuroimaging · GB

Funding

Wellcome Trust 056750Wellcome Trust 088130
6 · The paper itself

Abstract

Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal functional integration of brain processes. While the evidence for dysconnectivity in schizophrenia is strong, its etiology, pathophysiological mechanisms, and significance for clinical symptoms are unclear. First, dysconnectivity could result from aberrant wiring of connections during development, from aberrant synaptic plasticity, or from both. Second, it is not clear how schizophrenic symptoms can be understood mechanistically as a consequence of dysconnectivity. Third, if dysconnectivity is the primary pathophysiology, and not just an epiphenomenon, then it should provide a mechanistic explanation for known empirical facts about schizophrenia. This article addresses these 3 issues in the framework of the dysconnection hypothesis. This theory postulates that the core pathology in schizophrenia resides in aberrant N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic plasticity due to abnormal regulation of NMDARs by neuromodulatory transmitters like dopamine, serotonin, or acetylcholine. We argue that this neurobiological mechanism can explain failures of self-monitoring, leading to a mechanistic explanation for first-rank symptoms as pathognomonic features of schizophrenia, and may provide a basis for future diagnostic classifications with physiologically defined patient subgroups. Finally, we test the explanatory power of our theory against a list of empirical facts about schizophrenia.

Indexed as

Reality TestingSchizophrenic PsychologyAcetylcholineAwarenessBrainDelusionsDopamineElectroencephalographyHallucinationsHumansMagnetic Resonance ImagingMagnetoencephalographyNerve NetNeuronal PlasticityReceptors, N-Methyl-D-AspartateSchizophreniaAcetylcholineDopamineReceptors, N-Methyl-D-AspartateSerotonin

Identifiers

PMID19155345
PMCPMC2669579
OpenAlexW2095651675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.