Trial reportMetabolism: clinical and experimental2009
Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults.
Trial report in Metabolism: clinical and experimental, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01369043 (Modulation of Insulin and Exercise Responses by Vitamin E and Vitamin C), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulation of Insulin and Exercise Responses by Vitamin E and Vitamin C
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Triangulating evidence for the causal impact of single-intervention zinc supplement on glycaemic control for type 2 diabetes: systematic review and meta-analysis of randomised controlled trial and two-sample Mendelian randomisation.The British journal of nutrition · 2023Pooled it
- Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.The Cochrane database of systematic reviews · 2012Pooled it
- Metabolic and Neuroenergetic Effects of Intranasal Vitamin C Application in the Human Brain.Nutrients · 2025Trial
- Intake of antioxidants and risk of type 2 diabetes in a cohort of male smokers.European journal of clinical nutrition · 2011Trial
- The association of the composite dietary antioxidant index with the risk of cardiometabolic disorders: findings from the Tehran Lipid and Glucose Study.Journal of health, population, and nutrition · 2026Article
- Vitamin C intake is a novel potential therapeutic approach in the secretion of adiponectin and in the treatment of abdominal obesity.Caspian journal of internal medicine · 2026Article
- Dietary antioxidant index and cardiometabolic risks in normal-weight individuals: Evidence from the National Health and Nutrition Examination Survey.Asia Pacific journal of clinical nutrition · 2025Article
- The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells.Cell and tissue research · 2025Article
- Antidiabetic effect of dried sweet potato extract with fermented lettuce extracts.Food science and biotechnology · 2025Article
- Functional and Therapeutic Roles of Plant-Derived Antioxidants in Type 2 Diabetes Mellitus: Mechanisms, Challenges, and Considerations for Special Populations.Antioxidants (Basel, Switzerland) · 2025Review
- Does Iodine Influence the Metabolism of Glucose?Medicina (Kaunas, Lithuania) · 2023Review
- The Relationship between Obesity-Related Factors and Graves' Orbitopathy: A Pilot Study.Medicina (Kaunas, Lithuania) · 2022Article
- Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review.Journal of physiology and biochemistry · 2022Review
- The Association of Dietary Total Antioxidant Capacity with Inflammatory Biomarkers and Anthropometric Indices in Patients Who Candidate for Coronary Artery Bypass Graft Surgery: a Cross-sectional Study.Clinical nutrition research · 2021Article
- Antidiabetic Effect of Noodles Containing Fermented Lettuce Extracts.Metabolites · 2021Article
- Reactive oxygen species in exercise and insulin resistance: Working towards personalized antioxidant treatment.Redox biology · 2021Review
- Article
- Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives.International journal of molecular sciences · 2019Review
- Effect of dietary antioxidant-rich foods combined with aerobic training on energy metabolism in healthy young men.Journal of clinical biochemistry and nutrition · 2019Article
- Lutein attenuates oxidative stress markers and ameliorates glucose homeostasis through polyol pathway in heart and kidney of STZ-induced hyperglycemic rat model.European journal of nutrition · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of the study was to determine whether short-term antioxidant (AOX) supplementation affects insulin sensitivity, endothelial adhesion molecule levels, and oxidative stress in overweight young adults. A randomized, double-blind, controlled study tested the effects of AOXs on measures of insulin sensitivity (homeostasis model assessment [HOMA]) and quantitative insulin sensitivity check index), endothelial adhesion molecules (soluble intercellular adhesion molecule-1, vascular adhesion molecule, and endothelial-leukocyte adhesion molecule-1), adiponectin, and oxidative stress (lipid hydroperoxides) in overweight and normal-weight individuals (N = 48, 18-30 years). Participants received either AOX (vitamin E, 800 IU; vitamin C, 500 mg; beta-carotene, 10 mg) or placebo for 8 weeks. The HOMA values were initially higher in the overweight subjects and were lowered with AOX by week 8 (15% reduction, P = .02). Adiponectin increased in both AOX groups. Soluble intercellular adhesion molecule-1 and endothelial-leukocyte adhesion molecule-1 decreased in overweight AOX-treated groups by 6% and 13%, respectively (P < .05). Plasma lipid hydroperoxides were reduced by 0.31 and 0.70 nmol/mL in the normal-weight and overweight AOX-treated groups, respectively, by week 8 (P < .05). Antioxidant supplementation moderately lowers HOMA and endothelial adhesion molecule levels in overweight young adults. A potential mechanism to explain this finding is the reduction in oxidative stress by AOX. Long-term studies are needed to determine whether AOXs are effective in suppressing diabetes or vascular activation over time.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.