ArticleMetabolism: clinical and experimental2009
Combined hyperlipidemia in relation to race/ethnicity, obesity, and insulin resistance in the Multi-Ethnic Study of Atherosclerosis.
Article in Metabolism: clinical and experimental, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
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- A systematic review of overweight, obesity, and type 2 diabetes among Asian American subgroups.Current diabetes reviews · 2013Pooled it
- Racial and ethnic differences in controlling risk factors for cardiovascular disease among adults with obesity, 1999-2023.International journal of obesity (2005) · 2026Article
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- Structural and social determinants of health: The multi-ethnic study of atherosclerosis.PloS one · 2024Article
- Correlations between Coffee Consumption and Metabolic Phenotypes, Plasma Folate, and Vitamin B12: NHANES 2003 to 2006.Nutrients · 2021Article
- Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review.Current diabetes reports · 2018Review
- Optimal Scene Time to Achieve Favorable Outcomes in Out-of-hospital Cardiac Arrest: How Long Is Too Long?Cureus · 2018Article
- Atypical Antipsychotics and the Risk of Hyperlipidemia: A Sequence Symmetry Analysis.Drug safety · 2015Article
- American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program.Circulation · 2015Article
- Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation.American journal of physiology. Endocrinology and metabolism · 2013Article
- Commentary: Shaper and Jones, 'serum-cholesterol, diet and coronary heart-disease in Africans and Asians in Uganda': 50-year-old findings only need interpretational fine tuning to come up to speed!International journal of epidemiology · 2012Article
- Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association.International journal of nephrology · 2012Article
- Carotid artery intima-media thickness in college students: race/ethnicity matters.Atherosclerosis · 2011Article
- Univariate and bivariate linkage analysis identifies pleiotropic loci underlying lipid levels and type 2 diabetes risk.Annals of human genetics · 2010Article
- Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We have asked whether the prevalence of combined hyperlipidemia (CHL) differs by race/ethnicity, obesity, and insulin resistance in a contemporary, multiethnic, US cohort. We determined the prevalence and adjusted odds of CHL in a cohort of 5923 men and women free of clinically recognized cardiovascular disease and diabetes according to race/ethnicity (white, Chinese, African American, and Hispanic), obesity, and insulin resistance. Untreated lipid values were imputed for those on lipid-lowering therapy. Combined hyperlipidemia was defined using age- and sex-specific greater than or equal to 75th percentile cut points for low-density lipoprotein cholesterol and triglycerides obtained from a predominantly white North American population study. Compared with whites, adjusted odds ratios for CHL were 0.48 in African Americans (95% confidence interval [CI], 0.30-0.75), 1.33 in Hispanics (95% CI, 0.93-1.91), and 1.06 in Asians (95% CI, 0.62-1.82). Within the entire population, the adjusted odds of CHL were over 2-fold higher in overweight and obese participants compared with normal-weight participants and more than 4-fold higher in quartiles 2 through 4 of insulin resistance compared with quartile 1. African Americans had lower odds for CHL than whites despite higher body mass index and abdominal adiposity. Hispanics had a nonsignificantly higher trend, and Asians had no significantly different odds than whites. Modest increases in weight and insulin resistance were associated with significantly higher odds of CHL in a multiethnic US population. Further research is needed to determine the most efficacious diet, exercise, and drug management to decrease the risk of CHL and coronary heart disease among racial/ethnic groups in the United States.
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Registered trials
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