ArticleNeuroscience letters2009
GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
Article in Neuroscience letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- ERK1/2-Dependent Phosphorylation of GABAInternational journal of molecular sciences · 2023Article
- Ectopic activation of GABANature ecology & evolution · 2021Article
- GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper.Molecular psychiatry · 2016Article
- Receptor trafficking and the regulation of synaptic plasticity by SUMO.Neuromolecular medicine · 2013Review
- Rab family proteins regulate the endosomal trafficking and function of RGS4.The Journal of biological chemistry · 2013Article
- Neuronal Functions of ESCRTs.Experimental neurobiology · 2012Article
- The ocular albinism type 1 (OA1) GPCR is ubiquitinated and its traffic requires endosomal sorting complex responsible for transport (ESCRT) function.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Activity-dependent SUMOylation of the brain-specific scaffolding protein GISP.Biochemical and biophysical research communications · 2011Article
- Frontotemporal dementia caused by CHMP2B mutations.Current Alzheimer research · 2011Review
- Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation.Neuroscience letters · 2011Article
- Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations.Human molecular genetics · 2010Article
- Ischaemia differentially regulates GABA(B) receptor subunits in organotypic hippocampal slice cultures.Neuropharmacology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
GPCR interacting scaffold protein (GISP) is a multi-domain brain-specific scaffold protein that can regulate GABA(B) receptor complexes by both enhancing their surface expression and by inhibiting their lysosomal degradation. GISP retards degradation of GABA(B) receptors through its interaction with tumour susceptibility gene 101 (TSG101), a member of the endosomal sorting complex required for transport (ESCRT) lysosomal sorting machinery. We show that in addition to GABA(B), GISP exerts a more general role to increase the steady-state levels of several neurotransmitter receptors. Further, GISP delays TSG101-dependent agonist-induced EGFR down-regulation in human embryonic kidney (HEK) 293 cells whereas a mutant GISP lacking the TSG101 binding domain has no effect. These data suggest that GISP acts as a negative regulator of TSG101-dependent lysosomal degradation and plays an important role in determining the availability of neurotransmitter receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.