ArticleDevelopmental cell2009
Dystroglycan and perlecan provide a basal cue required for epithelial polarity during energetic stress.
Article in Developmental cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
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- Defects of full-length dystrophin trigger retinal neuron damage and synapse alterations by disrupting functional autophagy.Cellular and molecular life sciences : CMLS · 2021Article
- Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart.Scientific reports · 2017Article
- Glycomics: revealing the dynamic ecology and evolution of sugar molecules.Journal of proteomics · 2016Review
- Damage to the Drosophila follicle cell epithelium produces "false clones" with apparent polarity phenotypes.Biology open · 2013Article
- A Rab10-dependent mechanism for polarized basement membrane secretion during organ morphogenesis.Developmental cell · 2013Article
- Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer.The Journal of biological chemistry · 2013Article
- Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profile.BMC cell biology · 2012Article
- A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation.G3 (Bethesda, Md.) · 2012Article
- Expanding the morphogenetic repertoire: perspectives from the Drosophila egg.Developmental cell · 2012Article
- Polarization and myelination in myelinating glia.ISRN neurology · 2012Article
- Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.American journal of physiology. Renal physiology · 2011Article
- Extracellular matrix in development: insights from mechanisms conserved between invertebrates and vertebrates.Cold Spring Harbor perspectives in biology · 2011Review
- Extracellular matrix and its receptors in Drosophila neural development.Developmental neurobiology · 2011Review
- Translating cell polarity into tissue elongation.Seminars in cell & developmental biology · 2011Review
- Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan.Developmental cell · 2011Article
- Principles of planar polarity in animal development.Development (Cambridge, England) · 2011Review
- Global tissue revolutions in a morphogenetic movement controlling elongation.Science (New York, N.Y.) · 2011Article
- Article
- Tissue elongation requires oscillating contractions of a basal actomyosin network.Nature cell biology · 2010Article
Corrections and comments
- Retraction · 2013-10-28Doing the Right Thing · Error in Analyses · Error in Data · Unreliable Results and/or Conclusions ·
- Commented on by
- Retracted
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Dystroglycan localizes to the basal domain of epithelial cells and has been reported to play a role in apical-basal polarity. Here, we show that Dystroglycan null mutant follicle cells have normal apical-basal polarity, but lose the planar polarity of their basal actin stress fibers, a phenotype it shares with Dystrophin mutants. However, unlike Dystrophin mutants, mutants in Dystroglycan or in its extracellular matrix ligand Perlecan lose polarity under energetic stress. The maintenance of epithelial polarity under energetic stress requires the activation of Myosin II by the cellular energy sensor AMPK. Starved Dystroglycan or Perlecan null cells activate AMPK normally, but do not activate Myosin II. Thus, Perlecan signaling through Dystroglycan may determine where Myosin II can be activated by AMPK, thereby providing the basal polarity cue for the low-energy epithelial polarity pathway. Since Dystroglycan is often downregulated in tumors, loss of this pathway may play a role in cancer progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.