ArticleDevelopmental cell2009
Relaying the checkpoint signal from kinetochore to APC/C.
Article in Developmental cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Systems Biology Modeling of Five Pathways for Regulation and Potent Inhibition of the Anaphase-Promoting Complex (APC/C): Pivotal Roles for MCC and BubR1.Omics : a journal of integrative biology · 2015Article
- Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control.Computational and structural biotechnology journal · 2015Article
- Active transport can greatly enhance Cdc20:Mad2 formation.International journal of molecular sciences · 2014Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitotic checkpoint delays chromosome segregation until the last chromosome has correctly attached to the spindle. Exactly how this unattached chromosome can generate a checkpoint signal and inhibit the anaphase promoting complex/cyclosome (APC/C) is unknown. Two Developmental Cell papers in this issue by Kulukian et al. and Malureanu et al. now provide insight into how checkpoint components Mad2 and BubR1 relay the checkpoint signal from kinetochores to APC/C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.