Evidence map›Paper›PMID 19154710›Full record

ArticleDevelopmental cell2009

Dystroglycan and AMP kinase: polarity's protectors when the power goes out.

Li Zhang, Patricia Seo-Mayer, Michael J Caplan

Abstract readComment
In one paragraph

Article in Developmental cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Li ZhangDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06525, USA.
Patricia Seo-Mayer
Michael J Caplan

Funding

The Regulation of Renal Epithelial Cell Junction Assembly and PolarizationP01DK017433 · NIDDK · YALE UNIVERSITY · PI FORBUSH, BLISS · 1986 to 2018
$29.5M
Pathways and Partners in Renal Epithelial Cell PolarityR01DK072614 · NIDDK · YALE UNIVERSITY · PI CAPLAN, MICHAEL J. · 2005 to 2022
$6.9M
NIDDK NIH HHS P01 DK017433NIDDK NIH HHS R01 DK072614
6 · The paper itself

Abstract

The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosin regulatory light chain, making it available for phosphorylation by AMP kinase in response to energy stress.

Indexed as

Cell PolarityEpithelial CellsAdenylate KinaseAnimalsDystroglycansHeparan Sulfate ProteoglycansMyosin Light ChainsAdenylate KinaseDystroglycansHeparan Sulfate ProteoglycansMyosin Light Chainsperlecan

Identifiers

PMID19154710
PMCPMC2997531

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.