ArticleAnnals of general psychiatry2009
Isotretinoin and psychopathology: a review.
Article in Annals of general psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Oral isotretinoin for acne.The Cochrane database of systematic reviews · 2018Pooled it
- Influence of isotretinoin on hippocampal-based learning in human subjects.Psychopharmacology · 2012Trial
- Nightmares caused by isotretinoin in treating hidradenitis suppurativa: a case report and clinical insights.Dermatology reports · 2025Article
- Treatment Options for Juvenile Pityriasis Rubra Pilaris.Paediatric drugs · 2023Review
- Isotretinoin and adverse neuropsychiatric outcomes: retrospective cohort study using routine data.The British journal of dermatology · 2022Article
- Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed.Journal of affective disorders reports · 2021Article
- Isotretinoin Use and Risk of Depression in Acne Vulgaris Patients in Riyadh, Saudi Arabia.Cureus · 2021Article
- The association of depression, loneliness and internet addiction levels in patients with acne vulgaris.BioPsychoSocial medicine · 2020Article
- Isotretinoin-Induced Delusional Disorder, Somatic Subtype.Case reports in dermatological medicine · 2020Article
- Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris.Current therapeutic research, clinical and experimental · 2019Review
- Repositioning drugs by targeting network modules: a Parkinson's disease case study.BMC bioinformatics · 2017Article
- Can oral isotretinoin be safely initiated and monitored in primary care? A case series.Irish journal of medical science · 2017Article
- Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series.Drug safety - case reports · 2016Article
- Prolonged Inner Retinal Photoreception Depends on the Visual Retinoid Cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Inter-relationships between isotretinoin treatment and psychiatric disorders: Depression, bipolar disorder, anxiety, psychosis and suicide risks.World journal of psychiatry · 2015Review
- Personality traits and common psychiatric conditions in adult patients with acne vulgaris.Annals of dermatology · 2015Article
- Mefloquine use, psychosis, and violence: a retinoid toxicity hypothesis.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Evidence on acne therapy.Sao Paulo medical journal = Revista paulista de medicina · 2013Review
- Retinoic acid and affective disorders: the evidence for an association.The Journal of clinical psychiatry · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isotretinoin, a synthetic oral retinoid that is used against severe nodulocystic acne, has been associated with various psychiatric side effects such as depression, suicidality and psychotic symptoms. A great number of reports on its effects have been published since its introduction into the market. However, a causal relationship has not been established and the link between isotretinoin use and psychiatric events remains controversial. The present paper reviews the available evidence regarding the association of isotretinoin and psychiatric side effects. All published material reporting psychiatric side effects following isotretinoin treatment, including case reports, case series, reports from adverse drug event reporting systems, prospective surveys and retrospective case-control studies, are presented. In addition, the neurobiology of the retinoids and possible biological mechanisms that may lead to psychopathology are described.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.