ArticleGenetics2009
Rice Pi5-mediated resistance to Magnaporthe oryzae requires the presence of two coiled-coil-nucleotide-binding-leucine-rich repeat genes.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
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Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Comparative genome assemblies reveal distinct allelic and structural variation at blast resistance loci in rice CT21375-F4-4 and Moroberekan.The plant genome · 2026Article
- Genome-wide prediction of cloned disease resistance homologues across the Oryza genus.The plant genome · 2026Article
- Evaluating Blast Resistance of Huang-Huai Geng/Japonica Varieties Using Intragenic Markers.Rice (New York, N.Y.) · 2026Article
- OsnTNB.11 Encodes a CC-NBS-LRR Type Resistance Protein that Positively Regulates Resistance to Rice Kernel Smut by Modulating the Ethylene Signalling.Rice (New York, N.Y.) · 2025Article
- Research Progress on Rice-Blast-Resistance-Related Genes.Plants (Basel, Switzerland) · 2025Review
- A century of advances in molecular genetics and breeding for sustainable resistance to rice blast disease.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- An atypical NLR pair TdCNL1/TdCNL5 from wild emmer confers powdery mildew resistance in wheat.Nature genetics · 2025Article
- A pangenome reference of wild and cultivated rice.Nature · 2025Article
- Coordinated function of paired NLRs confers Yr84-mediated stripe rust resistance in wheat.Nature genetics · 2025Article
- Status on Genetic Resistance to Rice Blast Disease in the Post-Genomic Era.Plants (Basel, Switzerland) · 2025Review
- Transcriptomic analysis of rice cultivars with distinct resistance mechanisms toFrontiers in plant science · 2025Article
- Molecular breeding approaches for sustainable rice blast management: recent advances and challenges.Frontiers in plant science · 2025Review
- Allelic variation in rice blast resistance: a pathway to sustainable disease management.Molecular biology reports · 2024Review
- Examination of the Expression Profile of Resistance Genes in Yuanjiang Common Wild Rice (Genes · 2024Article
- An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function.Nature communications · 2024Article
- Pangenome-Wide Association Study and Transcriptome Analysis Reveal a Novel QTL and Candidate Genes Controlling both Panicle and Leaf Blast Resistance in Rice.Rice (New York, N.Y.) · 2024Article
- Development of an NLR-ID Toolkit and Identification of Novel Disease-Resistance Genes in Soybean.Plants (Basel, Switzerland) · 2024Article
- Recent Advances in Effector Research ofBiomolecules · 2023Review
- Genetic and molecular analysis of leaf blast resistance in Tetep derived line RIL4 and its relationship to genes at Pita/PitaScientific reports · 2023Article
42 more citing papers are in PubMed but not listed here.
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15 authors.
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Abstract
Rice blast, caused by the fungus Magnaporthe oryzae, is one of the most devastating diseases of rice. To understand the molecular basis of Pi5-mediated resistance to M. oryzae, we cloned the resistance (R) gene at this locus using a map-based cloning strategy. Genetic and phenotypic analyses of 2014 F2 progeny from a mapping population derived from a cross between IR50, a susceptible rice cultivar, and the RIL260 line carrying Pi5 enabled us to narrow down the Pi5 locus to a 130-kb interval. Sequence analysis of this genomic region identified two candidate genes, Pi5-1 and Pi5-2, which encode proteins carrying three motifs characteristic of R genes: an N-terminal coiled-coil (CC) motif, a nucleotide-binding (NB) domain, and a leucine-rich repeat (LRR) motif. In genetic transformation experiments of a susceptible rice cultivar, neither the Pi5-1 nor the Pi5-2 gene was found to confer resistance to M. oryzae. In contrast, transgenic rice plants expressing both of these genes, generated by crossing transgenic lines carrying each gene individually, conferred Pi5-mediated resistance to M. oryzae. Gene expression analysis revealed that Pi5-1 transcripts accumulate after pathogen challenge, whereas the Pi5-2 gene is constitutively expressed. These results indicate that the presence of these two genes is required for rice Pi5-mediated resistance to M. oryzae.
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