ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
Gastric mucus alterations associated with murine Helicobacter infection.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.Yonsei medical journal · 2018Article
- Trefoil Factor Peptides and Gastrointestinal Function.Annual review of physiology · 2017Review
- Gastric de novo Muc13 expression and spasmolytic polypeptide-expressing metaplasia during Helicobacter heilmannii infection.Infection and immunity · 2014Article
- Altered generation of induced regulatory T cells in the FVB.mdr1a-/- mouse model of colitis.Mucosal immunology · 2013Article
- Goblet cells and mucins: role in innate defense in enteric infections.Pathogens (Basel, Switzerland) · 2013Review
- Use of the cockroach antigen model of acute asthma to determine the immunomodulatory role of early exposure to gastrointestinal infection.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Helicobacter felis--associated gastric disease in microbiota-restricted mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen.The Journal of biological chemistry · 2010Article
- Review
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The C57BL/6 mouse has been shown to develop gastric adenocarcinoma after Helicobacter felis infection. This model was used to determine whether mucin and trefoil factor (TFF) expression after infection was altered in a similar fashion to the changes seen in the protective gastric mucus layer of the human stomach after H. pylori infection. Our results indicate that this mouse model mimics many of the changes seen after human H. pylori infection, including increased expression of muc4 and muc5b and loss of muc5ac. These alterations in mucin expression occurred as early as 4 weeks postinfection, before the development of significant mucous metaplasia or gastric dysplasia. The decrease in muc5ac expression occurred only in the body of the stomach and was not secondary to the adaptive immune response to infection, because a similar decrease in expression was seen after infection of B6.Rag-1(-/-) mice, which lack B and T cells. Intriguingly, the increased expression of Muc4 and Muc5b in infected C57BL/6 mice was not seen in the infected B6.Rag-1(-/-) mice. Because B6.Rag-1(-/-) mice do not develop gastric pathology after H. felis infection, these findings point to the potential role of Muc4 and Muc5b in disease progression. This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.