ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
Disruption of Nfic causes dissociation of odontoblasts by interfering with the formation of intercellular junctions and aberrant odontoblast differentiation.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Nuclear factor I-C regulates intramembranous bone formation via control of FGF signalling.Heliyon · 2025Article
- Roles of the NFI/CTF gene family in transcription and development: update 2025.Academia biology · 2025Article
- Comparison of osteogenic and dentinogenic potentials of mice incisor and molar pulps in vitro.Archives of oral biology · 2020Article
- NFIC promotes the vitality and osteogenic differentiation of rat dental follicle cells.Journal of molecular histology · 2019Article
- Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.Journal of molecular histology · 2019Article
- Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma.Neoplasia (New York, N.Y.) · 2018Article
- The fate of Osterix-expressing mesenchymal cells in dental root formation and maintenance.Orthodontics & craniofacial research · 2017Article
- The role of nuclear factor I-C in tooth and bone development.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2017Review
- Dentin sialoprotein facilitates dental mesenchymal cell differentiation and dentin formation.Scientific reports · 2017Article
- An Nfic-hedgehog signaling cascade regulates tooth root development.Development (Cambridge, England) · 2015Article
- Expression of Nfic during root formation in first mandibular molar of rat.Journal of molecular histology · 2014Article
- Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation.Developmental biology · 2013Article
- Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium.International journal of oral science · 2013Article
- Intrahepatic infiltrating NK and CD8 T cells cause liver cell death in different phases of dengue virus infection.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
We reported previously that Nfic-deficient mice exhibit short and abnormal molar roots and severely deformed incisors. The objective of this study is to address the mechanisms responsible for these changes using morphological, IHC, and RT-PCR analysis. Nfic-deficient mice exhibited aberrant odontoblasts and abnormal dentin formation in molar roots and the labial crown analog of incisors. The most striking changes observed in these aberrant odontoblasts were the loss of intercellular junctions and the decreased expression of ZO-1 and occludin. As a result, they became dissociated, had a round shape, and lost their cellular polarity and arrangement as a sheet of cells. Furthermore, the dissociated odontoblasts became trapped in dentin-like mineralized tissue, resembling osteodentin in the overall morphology. These findings suggest that loss of the Nfic gene interferes with the formation of intercellular junctions that causes aberrant odontoblast differentiation and abnormal dentin formation. Collectively, these changes in odontoblasts contributed to development of molars with short and abnormal roots in Nfic-deficient mice.
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