ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of Oatp1.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract.International journal of molecular sciences · 2020Review
- Expression of renal Oat5 and NaDC1 transporters in rats with acute biliary obstruction.World journal of gastroenterology · 2015Article
- Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis.Drug metabolism and disposition: the biological fate of chemicals · 2015Article
- Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Drug disposition alterations in liver disease: extrahepatic effects in cholestasis and nonalcoholic steatohepatitis.Expert opinion on drug metabolism & toxicology · 2014Review
- Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.World journal of gastroenterology · 2012Review
- Endocrine and metabolic regulation of renal drug transporters.Journal of biochemical and molecular toxicology · 2012Review
- Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice.Comparative hepatology · 2012Article
- Effects of synthetic androgens on liver function using the rabbit as a model.Journal of andrologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kidneys and liver are the major routes for organic anion elimination. We have recently shown that acute obstructive jaundice is associated with increased systemic and renal elimination of two organic anions, p-aminohippurate and furosemide, principally excreted through urine. This study examined probable adaptive mechanisms involved in renal elimination of bromosulfophthalein (BSP), a prototypical organic anion principally excreted in bile, in rats with acute obstructive jaundice. Male Wistar rats underwent bile duct ligation (BDL rats). Pair-fed sham-operated rats served as controls. BSP renal clearance was performed by conventional techniques. Renal organic anion-transporting polypeptide 1 (Oatp1) expression was evaluated by immunoblotting and IHC. Excreted, filtered, and secreted loads of BSP were all higher in BDL rats compared with Sham rats. The higher BSP filtered load resulted from the increase in plasma BSP concentration in BDL rats, because glomerular filtration rate showed no difference with the Sham group. The increase in the secreted load might be explained by the higher expression of Oatp1 observed in apical membranes from kidneys of BDL animals. This likely adaptation to hepatic injury, specifically in biliary components elimination, might explain, at least in part, the huge increase in BSP renal excretion observed in this experimental model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.