ArticleThe Journal of physiology2009
Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Using a Failing Human Ventricular Cardiomyocyte Model to Re-Evaluate CaBiomolecules · 2024Article
- CaJournal of molecular and cellular cardiology · 2023Article
- Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling.The Journal of general physiology · 2022Review
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Article
- Ca2+ channel nanodomains boost local Ca2+ amplitude.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Yoga for the sinoatrial node: sarcoplasmic reticulum calcium release confers flexibility.Journal of molecular and cellular cardiology · 2013Article
- Exploiting mathematical models to illuminate electrophysiological variability between individuals.The Journal of physiology · 2012Review
- Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.Journal of molecular and cellular cardiology · 2012Review
- Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries.Frontiers in physiology · 2012Article
- Dynamics of calcium sparks and calcium leak in the heart.Biophysical journal · 2011Article
- Microdomain [Ca²⁺] near ryanodine receptors as reported by L-type Ca²⁺ and Na+/Ca²⁺ exchange currents.The Journal of physiology · 2011Article
- Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop.Circulation · 2010Article
- Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels.The Journal of physiology · 2010Article
- Control of Ca2+ release by action potential configuration in normal and failing murine cardiomyocytes.Biophysical journal · 2010Article
- Regression analysis for constraining free parameters in electrophysiological models of cardiac cells.PLoS computational biology · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We present a minimal mathematical model of Ca(2+) spark triggering under voltage-clamp conditions in ventricular myocytes. The model predicts changes in excitation-contraction coupling 'gain' that result from diverse experimental interventions. We compare model results to several sets of data, and, in so doing, place apparent constraints on physiologically relevant model parameters. Specifically, the analysis suggests that many L-type Ca(2+) channel openings can potentially trigger each Ca(2+) spark, but the probability that an individual opening will trigger a spark is low. This procedure helps to reconcile contradictory results obtained in recent studies; moreover, this new model should be a useful tool for understanding changes in gain that occur physiologically and in disease.
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