Evidence map›Paper›PMID 19153139›Full record

ArticleNucleic acids research2009

Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR.

Roberto Marcucci, Maurizio Romano, Fabian Feiguin, Mary A O'Connell, Francisco E Baralle

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Roberto MarcucciInternational Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012, Italy.
Maurizio Romano
Fabian Feiguin
Mary A O'Connell
Francisco E Baralle
University of Trieste · ITInternational Centre for Genetic Engineering and Biotechnology · ITWestern General Hospital · GB

Funding

Medical Research Council MC_U127584490Telethon GGP06147
6 · The paper itself

Abstract

In Drosophila melanogaster, the expression of adenosine deaminase acting on RNA is regulated by transcription and alternative splicing so that at least four different isoforms are generated that have a tissue-specific splicing pattern. Even though dAdar has been extensively studied, the complete adult expression pattern has yet to be elucidated. In the present study, we investigate mature transcripts of dAdar arising from different promoters. Two predominant isoforms of dAdar are expressed in gonads and dAdar is transcribed from both the embryonic and the adult promoters. Furthermore, full-length transcripts containing the alternatively spliced exon-1 are expressed in a tissue-specific manner. The splicing factor B52/SRp55 binds within the alternative spliced exon 3a and plays a role in this alternative splicing event.

Indexed as

Alternative SplicingAdenosine DeaminaseAnimalsBinding SitesCell LineDrosophila melanogasterDrosophila ProteinsExonsFemaleIsoenzymesMaleNuclear ProteinsOocytesOvaryPhosphoproteinsRNA-Binding ProteinsADARB1 protein, humanAdenosine DeaminaseB52 protein, DrosophilaDrosophila ProteinsIsoenzymesNuclear ProteinsPhosphoproteinsRNA-Binding ProteinsRNA, MessengerRNA Splicing Factors

Identifiers

PMID19153139
PMCPMC2655694
OpenAlexW2160626242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.