ArticleMicrocirculation (New York, N.Y. : 1994)2009
AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of K(ATP) channels and heme oxygenase.
Article in Microcirculation (New York, N.Y. : 1994), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.Inflammopharmacology · 2022Article
- Preconditioning with the BKAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation.The Journal of surgical research · 2015Article
- The 5'-AMP-Activated Protein Kinase (AMPK) Is Involved in the Augmentation of Antioxidant Defenses in Cryopreserved Chicken Sperm.PloS one · 2015Article
- Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers.Nephron. Experimental nephrology · 2014Article
- Commentaries on viewpoint: A paradigm shift for local blood flow regulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice.American journal of physiology. Heart and circulatory physiology · 2013Article
- Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review.World journal of gastroenterology · 2013Review
- Activation of AMP-activated protein kinase inhibits the proliferation of human endothelial cells.The Journal of pharmacology and experimental therapeutics · 2012Article
- AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney.British journal of pharmacology · 2012Article
- Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms.Journal of molecular and cellular cardiology · 2012Review
- Hydrogen sulfide preconditioning or neutrophil depletion attenuates ischemia-reperfusion-induced mitochondrial dysfunction in rat small intestine.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions.American journal of physiology. Heart and circulatory physiology · 2011Article
- Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival.American journal of physiology. Heart and circulatory physiology · 2011Article
- Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences.Langenbeck's archives of surgery · 2011Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe previously demonstrated that pharmacologic activation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR) 24 hours prior to (AICAR preconditioning; AICAR-PC) ischemia/reperfusion (I/R) prevents postischemic leukocyte-endothelial cell adhesive interactions (LEI) by a mechanism initiated by endothelial nitric oxide synthase (eNOS)-dependent NO production during the period of AICAR-PC. The major aim of this study was to examine the role of ATP-sensitive potassium (K(ATP)) channels and heme oxygenase as mediators of the antiadhesive effects of AICAR-PC during I/R 24 hours later.
methodsIntravital fluorescence microscopy was used to quantify LEI in the small intestine of AICAR-preconditioned C57BL/6J mice treated with K(ATP) channel or heme oxygenase inhibitors during I/R 24 hours after AICAR-PC in separate experiments.
resultsI/R induced marked increases in LEI relative to sham control mice, proadhesive responses that were prevented by AICAR-PC 24 hours prior to I/R. The effects of AICAR-PC to prevent postischemic LEI were abolished by K(ATP) channel or heme oxygenase inhibition during I/R. DISCUSSION/
conclusionOur results indicate that the antiadhesive effects of AICAR-PC are mediated by K(ATP) channel- and heme oxygenase-dependent mechanisms during I/R.
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