Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
123I-mIBG scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: design of two prospective multicenter international trials.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03227393 (The Effect of Yoga on Cardiac Sympathetic Innervation Evaluated by I-123 mIBG), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Yoga on Cardiac Sympathetic Innervation Evaluated by I-123 mIBG
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- The prognostic value ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Pooled it
- Prognostic usefulness of planarJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- Impact of an exercise training program on cardiac neuronal function in heart failure patients on optimal medical therapy : A randomized Iodine-123 metaiodobenzylguanidine scintigraphy study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Trial
- The relationship of left ventricular mechanical dyssynchrony and cardiac sympathetic denervation to potential sudden cardiac death events in systolic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Quantitative I-123 mIBG SPECT in differentiating abnormal and normal mIBG myocardial uptake.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Trial
- Myocardial Sympathetic Innervation Imaging.Journal of nuclear medicine technology · 2025Article
- Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes.Current cardiology reports · 2025Review
- Impaired Cardiac Sympathetic Activity Is Associated With Myocardial Remodeling and Established Biomarkers of Heart Failure.Journal of the American Heart Association · 2024Article
- A simplified wall-based model for regional innervation/perfusion mismatch assessed by cardiac 123I-mIBG and rest 99mTc-tetrofosmin SPECT to predict arrhythmic events in ischaemic heart failure.European heart journal. Cardiovascular Imaging · 2022Article
- CardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- How do we establish cardiac sympathetic nervous system imaging withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Neuro-cardiac imaging has a proven value in patient management: Con.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Assessment ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Ventricular arrhythmias and autonomic nervous system: evolving role of radionuclide imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Current Clinical Applications and Next Steps for Cardiac Innervation Imaging.Current cardiology reports · 2017Review
- It's not all in the numbers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Quantitative iodine-123-metaiodobenzylguanidine (MIBG) SPECT imaging in heart failure with left ventricular systolic dysfunction: Development and validation of automated procedures in conjunction with technetium-99m tetrofosmin myocardial perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Individuals with impaired glucose tolerance demonstrate normal cardiac sympathetic innervation using I-123 mIBG scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Cardiac sympathetic imaging in the diagnosis of cardiac autonomic neuropathy in pre-diabetes.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) consists of two identical prospective open-label, multicenter, phase 3 studies (MBG311 and MBG312) evaluating the prognostic usefulness of (123)I-mIBG scintigraphy for identifying subjects with heart failure who will experience a major adverse cardiac event.
methodsSubjects with NYHA class II and III heart failure and left ventricular ejection fraction < or = 35% were eligible for the trials. Subjects underwent planar and SPECT (123)I-mIBG myocardial imaging, as well as echocardiography and gated SPECT (99m)Tc-tetrofosmin myocardial perfusion imaging. Subjects are then monitored on a regular basis for 2 years. Time to first occurrence of one of the following--NYHA class progression; potentially life-threatening arrhythmic event (including ICD discharge); or cardiac death, as verified by an independent adjudication panel---will be analyzed in comparison to quantitative parameters derived from (123)I-mIBG imaging. The primary efficacy analysis will employ the heart/mediastinum ratio on 4-hour delayed planar imaging, while secondary efficacy analyses will examine quantitative results from both planar and SPECT (123)I-mIBG images, as well as from (99m)Tc-tetrofosmin SPECT and echocardiography.
conclusionThe results of the ADMIRE-HF trials will provide prospective validation of the potential role of (123)I-mIBG scintigraphy in assessing prognosis and developing management strategies for patients with heart failure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.