ArticleDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete2009
[Generation of reactive oxygen species in vitro by Malassezia yeasts].
Article in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Understanding the dandruff flare-up: A cascade of measurable and perceptible changes to scalp health.International journal of cosmetic science · 2025Trial
- Malassezia May Contribute to Basal Cell Carcinoma Development via Inflammatory and Oxidative Stress Pathways.MicrobiologyOpen · 2026Article
- Skin microbiome engineering: Challenges and opportunities in skin diseases treatment.iMetaOmics · 2025Review
- Anti-Microorganisms · 2023Review
- Interactions betweenInternational journal of molecular sciences · 2023Article
- Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle.Antioxidants (Basel, Switzerland) · 2023Review
- Thiol-Disulfide Homeostasis in Skin Diseases.Journal of clinical medicine · 2022Review
- The Role of Reactive Oxygen Species and Nitric Oxide in the Inhibition ofOxidative medicine and cellular longevity · 2020Article
- [Malassezia folliculitis in an immunocompromised patient].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2011Article
- Scalp Condition Impacts Hair Growth and Retention via Oxidative Stress.International journal of trichologyReview
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
methodsFree oxygen species are able to destroy cells due to their cytotoxic effect, which is based on lipid peroxidation, enzyme oxidation and protein oxidation. We analyzed the ability of six different Malassezia (M.) species to generate reactive oxygen species (ROS), using the lucigenin-amplified chemiluminescence. Further investigations showed the effect of different concentrations of terbinafine on ROS generation by M. furfur and M. pachydermatis after 10, 30 and 60 minutes.
resultsAll of the investigated Malassezia species (M. furfur, M. globosa, M. sympodialis, M. slooffiae, M. obtusa, M. pachydermatis) was able to generate reactive oxygen species. Terbinafine inhibited free radical production by M. furfur and M. pachydermatis.
conclusionDependent on their cell concentrations, M. species have the ability to generate ROS. The ability of the different Malassezia species to produce ROS should be considered as one further virulence factor of this yeast. The antifungal agent terbinafine (concentrations from 100 microg to 1 microg ml -1) reduced ROS production by M. furfur and M. pachydermatis. Terbinafine acts as oxygen species scavenger. This could be an additional mechanism supporting the classic antifungal effect of this agent, the inhibition of ergosterol synthesis.
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