ArticleNature chemical biology2009
Metabolic reprogramming of periwinkle plant culture.
Article in Nature chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Reflecting on 20 years of progress.Nature chemical biology · 2025Article
- Review
- The Pictet-Spengler Reaction Updates Its Habits.Molecules (Basel, Switzerland) · 2020Review
- Deploying Microbial Synthesis for Halogenating and Diversifying Medicinal Alkaloid Scaffolds.Frontiers in bioengineering and biotechnology · 2020Review
- Unnatural spirocyclic oxindole alkaloids biosynthesis in Uncaria guianensis.Scientific reports · 2019Article
- Furan-Site Bromination and Transformations of Fraxinellone as Insecticidal Agents Against Mythimna separata Walker.Scientific reports · 2018Article
- Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging.Scientific reports · 2016Article
- The chemical logic of plant natural product biosynthesis.Current opinion in plant biology · 2014Article
- Palladium-catalyzed transformations of salvinorin A, a neoclerodane diterpene from Salvia divinorum.Organic letters · 2013Article
- The role of biocatalysis in the asymmetric synthesis of alkaloids.RSC advances · 2013Review
- Emulating the logic of monoterpenoid alkaloid biogenesis to access a skeletally diverse chemical library.The Journal of organic chemistry · 2013Article
- Recent progress in the metabolic engineering of alkaloids in plant systems.Current opinion in biotechnology · 2013Review
- A high-throughput screen for the engineered production of β-lactam antibiotics.ACS chemical biology · 2012Article
- Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules.Plant biotechnology journal · 2012Review
- Metabolic engineering for the production of natural products.Annual review of chemical and biomolecular engineering · 2011Review
- A decade of chemical biology.Nature chemical biology · 2010Article
- Article
- Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production.Plant cell reports · 2010Article
- Natural products version 2.0: connecting genes to molecules.Journal of the American Chemical Society · 2010Article
- Mechanistic advances in plant natural product enzymes.Current opinion in chemical biology · 2009Review
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2 authors.
Funding
Abstract
We transformed an alkaloid biosynthetic gene with reengineered substrate specificity into Catharanthus roseus. The resulting transgenic plant cell culture produced a variety of unnatural alkaloid compounds when cocultured with simple, achiral, commercially available precursors that the reengineered enzyme was designed to accept. This work demonstrates the power of genetic engineering to retailor the structures of complex alkaloid natural products in plant culture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.