ArticleInvestigative ophthalmology & visual science2009
Protective role of gammadelta T cells in spontaneous ocular inflammation.
Article in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- Immune cell dynamics and cytokine regulation in cornea and transplantation.Frontiers in immunology · 2026Review
- The Ocular Surface Microbiome in Homeostasis and Dysbiosis.Microorganisms · 2025Review
- The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea.The ocular surface · 2023Article
- Mucosal immunology of the ocular surface.Mucosal immunology · 2022Review
- The Human Tissue-Engineered Cornea (hTEC): Recent Progress.International journal of molecular sciences · 2021Review
- Intramuscular Vaccination With the HSV-1(VC2) Live-Attenuated Vaccine Strain Confers Protection Against Viral Ocular Immunopathogenesis Associated With γδT Cell Intracorneal Infiltration.Frontiers in immunology · 2021Article
- Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis.eLife · 2020Article
- Distribution of Interleukin-22-secreting Immune Cells in Conjunctival Associated Lymphoid Tissue.Korean journal of ophthalmology : KJO · 2018Article
- Review: The function of regulatory T cells at the ocular surface.The ocular surface · 2017Review
- Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities.International journal of molecular sciences · 2017Review
- γδ T Cell-Dependent Regulatory T Cells Prevent the Development of Autoimmune Keratitis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells.Investigative ophthalmology & visual science · 2012Article
- The accumulation and prognosis value of tumor infiltrating IL-17 producing cells in esophageal squamous cell carcinoma.PloS one · 2011Article
- Topical flagellin protects the injured corneas from Pseudomonas aeruginosa infection.Microbes and infection · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
purposeA role for gammadelta T cells in immunoregulation has been shown in a number of studies, but in the absence of infection or induced disease, mice lacking gammadelta T cells generally appear to be healthy. That certain mice lacking gammadelta T cells often spontaneously develop keratitis, characterized by a progressive and destructive inflammation of the cornea is reported here.
methodsThe keratitis developing in these mice was characterized in terms of prevalence in males versus females, age of onset, and histologic features. Attempts were made to understand the underlying causes of the disease by removing alphabeta T cells, altering sex hormones, and reconstituting gammadelta T cells.
resultsThe development of keratitis in these mice depended on the C57BL/10 genetic background, and was much more common among females than males. The incidence of the disease increased with age, exceeding 80% in females greater than 18 weeks old. Evidence that the keratitis in these mice is at least partly autoimmune in nature, and that despite its prevalence in females, male hormones do not protect against the disease is presented.
conclusionsThese findings indicate an important role for gammadelta T cells in maintaining immune balance in the eye. The mice described in this study represent a potential new small animal model of keratitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.