SynthesisInvestigative ophthalmology & visual science2009
Genomewide linkage scans for ocular refraction and meta-analysis of four populations in the Myopia Family Study.
Synthesis in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Myopia in African Americans Is Significantly Linked to Chromosome 7p15.2-14.2.Investigative ophthalmology & visual science · 2021Article
- The GGLEAM Study: Understanding Glaucoma in the Ohio Amish.International journal of environmental research and public health · 2021Article
- Pathogenesis and Prevention of Worsening Axial Elongation in Pathological Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2020Review
- Linear mixed models for association analysis of quantitative traits with next-generation sequencing data.Genetic epidemiology · 2019Article
- IMI - Myopia Genetics Report.Investigative ophthalmology & visual science · 2019Review
- Controlling myopia progression in children and adolescents.Adolescent health, medicine and therapeutics · 2015Review
- AMP-activated protein kinase regulates intraocular pressure, extracellular matrix, and cytoskeleton in trabecular meshwork.Investigative ophthalmology & visual science · 2014Article
- An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error.Molecular vision · 2012Article
- An evidence-based update on myopia and interventions to retard its progression.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2011Article
- Nature and nurture: the complex genetics of myopia and refractive error.Clinical genetics · 2011Review
- Epidemiology, genetics and treatments for myopia.International journal of ophthalmology · 2011Article
- Identification of novel suggestive loci for high-grade myopia in Polish families.Molecular vision · 2011Article
- Dissecting the genetic heterogeneity of myopia susceptibility in an Ashkenazi Jewish population using ordered subset analysis.Molecular vision · 2011Article
- Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.Investigative ophthalmology & visual science · 2010Article
- Quasi-least squares with mixed linear correlation structures.Statistics and its interface · 2010Article
- AC and AG dinucleotide repeats in the PAX6 P1 promoter are associated with high myopia.Molecular vision · 2009Article
- Myopia genetics: a review of current research and emerging trends.Current opinion in ophthalmology · 2009Review
- Fine-mapping of candidate region in Amish and Ashkenazi families confirms linkage of refractive error to a QTL on 1p34-p36.Molecular vision · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeGenomewide linkage scans were performed in Caucasian (CAUC) and Old Order Amish (OOA) families to identify genomic regions containing genes responsible for refractive error control. We also performed a meta-analysis by combining these results with our previous linkage results from Ashkenazi Jewish (ASHK) and African American (AFRAM) families.
methodsTwo hundred seventy-one CAUC and 411 OOA participants (36 and 61 families, respectively) were recruited to participate in the Myopia Family Study. Recruitment criteria were designed to enrich the sample for multiplex myopic families. Genomewide, model-free, multipoint linkage analyses were performed separately for each population by using >370 microsatellite markers. Empirical significance levels were determined via gene-dropping simulations. A meta-analysis was performed by combining linkage results from the CAUC, OOA, AFRAM, and ASHK samples, and results were compared to previously reported loci for myopia and refraction.
resultsSuggestive evidence of linkage was found at 12q24 (LOD = 4.583, P = 0.00037) and 4q21 (LOD = 2.72, P = 0.0028) in the CAUC sample and at 5qter (LOD = 3.271, P = 0.0014) in the OOA. Meta-analysis linkage results were largely driven by population-specific signals from ASHK and AFRAM families. The meta-analysis showed suggestive evidence of linkage to 4q21-22 (meta-P = 0.00214) adjacent to the previously reported MYP9 and MYP11 loci.
conclusionsThe results showed suggestive evidence of linkage of ocular refraction to 12q24 and 4q21 in CAUC and to 5qter in OOA families. The meta-analysis supports the view that several genes play a role in refractive development across populations. In MFS families, four broad genomic regions (on 1p, 4q, 7p, and 12q) most likely contain genes that influence ocular refraction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.