ArticleEukaryotic cell2009
Uneven distribution of mating types among genotypes of Candida glabrata isolates from clinical samples.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- Review
- Regulation of meiotic gene expression is functional in the human fungal pathogen Candida glabrata.FEMS yeast research · 2025Article
- Transposon-sequencing (Tn-seq) of the Candida glabrata reference strain CBS138 reveals epigenetic plasticity, structural variation, and intrinsic mechanisms of resistance to micafungin.G3 (Bethesda, Md.) · 2024Article
- Short Tandem Repeat Genotyping of Medically Important Fungi: A Comprehensive Review of a Powerful Tool with Extensive Future Potential.Mycopathologia · 2024Review
- Ploidy evolution in a wild yeast is linked to an interaction between cell type and metabolism.PLoS biology · 2023Article
- Lessons from the Nakaseomyces: mating-type switching, DSB repair and evolution of Ho.Current genetics · 2021Review
- Molecular Typing of Candida glabrata.Mycopathologia · 2020Review
- Differential Regulation of Echinocandin Targets Fks1 and Fks2 inJournal of fungi (Basel, Switzerland) · 2020Article
- Fitness differences suppress the number of mating types in evolving isogamous species.Royal Society open science · 2020Article
- Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal.Current genetics · 2019Review
- Clinical and Laboratory Development of Echinocandin Resistance inFrontiers in microbiology · 2019Article
- Clonal Spread of Candida glabrata Bloodstream Isolates and Fluconazole Resistance Affected by Prolonged Exposure: a 12-Year Single-Center Study in Belgium.Antimicrobial agents and chemotherapy · 2018Article
- Mutant Prevention Concentration and Mutant Selection Window of Micafungin and Anidulafungin in Clinical Candida glabrata Isolates.Antimicrobial agents and chemotherapy · 2018Article
- Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans.Current biology : CB · 2018Article
- Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How?Clinical microbiology reviews · 2017Review
- Molecular Epidemiology and Antifungal Susceptibility ofFrontiers in microbiology · 2017Article
- Opportunistic fungal pathogen Candida glabrata circulates between humans and yellow-legged gulls.Scientific reports · 2016Article
- Multilocus microsatellite analysis of European and African Candida glabrata isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Evaluation of Polymorphic Locus Sequence Typing for Candida glabrata Epidemiology.Journal of clinical microbiology · 2016Article
- Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to shed light on its basic biology, we initiated a population genetic analysis of Candida glabrata, an emerging pathogenic yeast with no sexual stage yet recognized. A worldwide collection of clinical strains was subjected to analysis using variable number of tandem repeats (VNTR) at nine loci. The clustering of strains obtained with this method was congruent with that obtained using sequence polymorphism of the NMT1 gene, a locus previously proposed for lineage assignment. Linkage disequilibrium supported the hypothesis of a mainly clonal reproduction. No heterozygous diploid genotype was found. Minimum-spanning tree analysis of VNTR data revealed clonal expansions and associated genotypic diversification. Mating type analysis revealed that 80% of the strains examined are MATa and 20% MATalpha and that the two alleles are not evenly distributed. The MATa genotype dominated within large clonal groups that contained only one or a few MATalpha types. In contrast, two groups were dominated by MATalpha strains. Our data are consistent with rare independent mating type switching events occurring preferentially from type a to alpha, although the alternative possibility of selection favoring type a isolates cannot be excluded.
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