ArticleThe Plant cell2009
Multiple repeats of a promoter segment causes transcription factor autoregulation in red apples.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers.
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254 citing papers in PubMed, 534 citations in OpenAlex.
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- ZmWAK3 overexpression enhances cold tolerance via coordinated improvement of antioxidant defense and photosynthesis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Integrated metabolome and transcriptome analyses reveal the role played by CaWRKY44 during anthocyanins accumulation in pepper fruits.BMC plant biology · 2026Article
- A 725-bp quadruple repeat in the promoter ofHorticulture research · 2026Article
- Molecular insights into the regulation of flavonoid biosynthesis in fruits.Horticulture research · 2026Article
- Overexpression of a Tonoplast Malate Transporter Gene Leads to Enhanced Anthocyanin Biosynthesis in Apple.Plant biotechnology journal · 2026Article
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- Metabolic profiling of red-fleshed apple and functional characterization of MdERF072 in anthocyanin biosynthesis.BMC plant biology · 2025Article
- MYB regulator of "colorless" flavonols underlies the evolution of red flowers in Iochroma (Solanaceae).G3 (Bethesda, Md.) · 2025Article
- The grape berry methylome reveals tissue-specific features associated with metabolism in ripening.Horticulture research · 2025Article
- Anthocyanin accumulation in the red-fleshed grape germplasm ZhongShan-HongYu through bulked segregant analysis and RNA-seq.The plant genome · 2025Article
- A Repression-Activation System Involving miR164a-NACs Regulates Tissue-Specific Anthocyanin Accumulation in Peach Fruit.Plant biotechnology journal · 2025Article
- Rescue of tomato yellow leaf curl virus mutants harboring heterologous iterons throughJournal of virology · 2025Article
- Truncated CMV2bPlant methods · 2025Article
- Beyond IbMYB1: Identification and Characterization of Two Additional Anthocyanin MYB Activators, IbMYB2 and IbMYB3, in Sweetpotato.Plants (Basel, Switzerland) · 2025Article
- Convergent domestication of bitter apples and pears by selecting mutations of MYB transcription factors to reduce proanthocyanidin levels.Molecular horticulture · 2025Article
194 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the genes encoding for either the biosynthetic or transcriptional regulation of the anthocyanin pathway have been linked to color phenotypes. Generally, this is a loss of function resulting in a reduction or a change in the distribution of anthocyanin. Here, we describe a rearrangement in the upstream regulatory region of the gene encoding an apple (Malus x domestica) anthocyanin-regulating transcription factor, MYB10. We show that this modification is responsible for increasing the level of anthocyanin throughout the plant to produce a striking phenotype that includes red foliage and red fruit flesh. This rearrangement is a series of multiple repeats, forming a minisatellite-like structure that comprises five direct tandem repeats of a 23-bp sequence. This MYB10 rearrangement is present in all the red foliage apple varieties and species tested but in none of the white fleshed varieties. Transient assays demonstrated that the 23-bp sequence motif is a target of the MYB10 protein itself, and the number of repeat units correlates with an increase in transactivation by MYB10 protein. We show that the repeat motif is capable of binding MYB10 protein in electrophoretic mobility shift assays. Taken together, these results indicate that an allelic rearrangement in the promoter of MYB10 has generated an autoregulatory locus, and this autoregulation is sufficient to account for the increase in MYB10 transcript levels and subsequent ectopic accumulation of anthocyanins throughout the plant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.