ArticleJournal of bacteriology2009
Population variability of the FimH type 1 fimbrial adhesin in Klebsiella pneumoniae.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Prevalence of fimH and class I, II, and III integron-associated integrase genes among extensively drug-resistant Klebsiella pneumoniae isolates in Isfahan, Iran.Molecular biology reports · 2026Article
- Fosfomycin at sub-minimum inhibitory concentration impairs biofilm and efflux pump activity in multidrug-resistant Klebsiella pneumoniae isolates.BMC microbiology · 2026Article
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- Parallel within-host evolution alters virulence factors in an opportunistic Klebsiella pneumoniae during a hospital outbreak.Nature communications · 2025Article
- Genetic diversity, drug resistance, and biofilm formation in Klebsiella pneumoniae associated with nosocomial infection in Pelotas, RS, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Influence of the polysaccharide capsule on virulence and fitness ofFrontiers in microbiology · 2025Article
- Molecular characterization of Klebsiella pneumoniae in clinical bovine mastitis in 14 provinces in China.Veterinary research communications · 2024Article
- Conformational ensembles inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genomic Profile of a Multidrug-Resistant Klebsiella pneumoniae Strain Isolated from a Urine Specimen.Current microbiology · 2024Article
- Comprehensive Analysis of Virulence Genes, Antibiotic Resistance, Biofilm Formation, and Sequence Types in Clinical Isolates ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Article
- Serotyping and molecular profiles of virulence-associated genes amongHealth science reports · 2023Article
- Transcriptomic and phenotype analysis revealed the role ofFrontiers in cellular and infection microbiology · 2023Article
- Occurrence of blaArchives of microbiology · 2022Article
- Multidrug-Resistant Klebsiella variicola Isolated in the Urine of Healthy Bovine Heifers, a Potential Risk as an Emerging Human Pathogen.Applied and environmental microbiology · 2022Article
- Biofilm and Gene Expression Characteristics of the Carbapenem-Resistant Enterobacterales,International journal of environmental research and public health · 2022Article
- Context-aware genomic surveillance reveals hidden transmission of a carbapenemase-producingMicrobial genomics · 2021Article
- Forensic genomics of a novelMicrobial genomics · 2020Article
- Community- and Hospital-AcquiredMicroorganisms · 2019Article
- BamB and outer membrane biogenesis - The Achilles' heel for targeting Klebsiella infections?Virulence · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
FimH is an adhesive subunit of type 1 fimbriae expressed by different enterobacterial species. The enteric bacterium Klebsiella pneumoniae is an environmental organism that is also a frequent cause of sepsis, urinary tract infection (UTI), and liver abscess. Type 1 fimbriae have been shown to be critical for the ability of K. pneumoniae to cause UTI in a murine model. We show here that the K. pneumoniae fimH gene is found in 90% of strains from various environmental and clinical sources. The fimH alleles exhibit relatively low nucleotide and structural diversity but are prone to frequent horizontal-transfer events between different bacterial clones. Addition of the fimH locus to multiple-locus sequence typing significantly improved the resolution of the clonal structure of pathogenic strains, including the K1 encapsulated liver isolates. In addition, the K. pneumoniae FimH protein is targeted by adaptive point mutations, though not to the same extent as FimH from uropathogenic Escherichia coli or TonB from the same K. pneumoniae strains. Such adaptive mutations include a single amino acid deletion from the signal peptide that might affect the length of the fimbrial rod by affecting FimH translocation into the periplasm. Another FimH mutation (S62A) occurred in the course of endemic circulation of a nosocomial uropathogenic clone of K. pneumoniae. This mutation is identical to one found in a highly virulent uropathogenic strain of E. coli, suggesting that the FimH mutations are pathoadaptive in nature. Considering the abundance of type 1 fimbriae in Enterobacteriaceae, our present finding that fimH genes are subject to adaptive microevolution substantiates the importance of type 1 fimbria-mediated adhesion in K. pneumoniae.
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Registered trials
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